{"id":3372,"date":"2021-04-13T00:00:00","date_gmt":"2021-04-12T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3372"},"modified":"2021-04-13T00:00:00","modified_gmt":"2021-04-12T16:00:00","slug":"brief-introduction-of-methyl-2-methyl-5-oxo-25-dihydro-1h-pyrazole-3-carboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3372","title":{"rendered":"Brief introduction of Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate"},"content":{"rendered":"

52867-42-2, name is Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate<\/a><\/p>\n

To a solution of [5-(4-fluoro-phenyl)-3-methyl-3H-[l,2,3]triazol-4-yl]-methanol (290 mg, 1.4 mmol) in THF (30 mL) was added 5-hydroxy-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (218 mg, 1.4 mmol) and triphenylphosphine (477 mg, 1.82 mmol) at ambient temperature under an argon atmosphere. Then diethyl azodicarboxylate (641 mu, 3.5 mmol) was added and the reaction mixture was stirred for 16 h at room temperature. Concentration and purification by chromatography (silica, 20 to 50% ethyl acetate in heptane) afforded the title compound (483 mg, 100%) as a white solid. MS: m\/e = 346.2 [M+H]+.<\/p>\n

The synthetic route of 52867-42-2 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 52867-42-2 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[237,131],"tags":[126],"class_list":["post-3372","post","type-post","status-publish","format-standard","hentry","category-52867-42-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nBrief introduction of Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate<\/title>\n<meta name=\"description\" content=\"52867-42-2, name is Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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