{"id":3365,"date":"2021-04-13T00:00:00","date_gmt":"2021-04-12T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3365"},"modified":"2021-04-13T00:00:00","modified_gmt":"2021-04-12T16:00:00","slug":"discovery-of-5-bromo-1-methyl-1h-pyrazol-3-amine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3365","title":{"rendered":"Discovery of 5-Bromo-1-methyl-1H-pyrazol-3-amine"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89088-55-1, name is 5-Bromo-1-methyl-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Bromo-1-methyl-1H-pyrazol-3-amine<\/a><\/p>\n

To a solution of compound 45-3 (190 mg, 624.3 umol) in DCM (6.0 mL) was added DIEA (121 mg, 936.5 umol, 163.6 uL). The mixture was cooled to -20C for 0.5 h and then added bis(trichloromethyl) carbonate (61 mg, 206.0 umol) quickly avoiding water. The mixture was stirred at -20C for 0.5 h, and 5-bromo-l-methyl-lH-pyrazol-3-amine (109 mg, 624.3 umol) in DCM (4.0 mL) was added dropwise. The resulting mixture was stirred at 25C for 12 h and concentrated. The residue was purified by column chromatography (Si02) to afford compound 45-4 (62 mg).<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[379,131],"tags":[126],"class_list":["post-3365","post","type-post","status-publish","format-standard","hentry","category-89088-55-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nDiscovery of 5-Bromo-1-methyl-1H-pyrazol-3-amine<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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