{"id":3359,"date":"2021-04-13T00:00:00","date_gmt":"2021-04-12T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3359"},"modified":"2021-04-13T00:00:00","modified_gmt":"2021-04-12T16:00:00","slug":"application-of-5-chloro-3-trifluoromethyl-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3359","title":{"rendered":"Application of 5-Chloro-3-(trifluoromethyl)-1H-pyrazole"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 131797-35-8, name is 5-Chloro-3-(trifluoromethyl)-1H-pyrazole, A new synthetic method of this compound is introduced below., Product Details of 131797-35-8<\/a><\/p>\n

To a mixture of 7-(chloromethyl)-3-propanoyl-2-(trifluoromethyl)-5H-[l,3]thiazolo[3,2- a]pyrimidin-5-one (15 mg, 0.05mmol) in acetonitrile (3 mL, 57.1mmol) was added potassium carbonate (13 mg, 0.09 mmol) and 5-chloro-3-(trifluoromethyl)-lH-pyrazole (10 mg, 0.06 mmol). The resulting mixture was stirred for 2 h at 80 C. After filtration and concentration, the residue was purified by chromatography with ethyl acetate\/petroleum ether (1\/3) to afford 7-[[5-chloro-3-(trifluoromethyl)-lH- pyrazol-l-yl]methyl]-3-propanoyl-2-(trifluoromethyl)-5H-[l,3]thiazolo[3,2-a]pyrimidin-5-one (4.5 mg, 21%) as a light brown solid. LCMS (ESI): M+H+ = 459.0; lU NMR (400 MHz, CDC13) delta 6.60 (s, 1H), 5.83 (s, 1H), 5.31 (s, 2H), 2.97-2.83 (m, 2H), 1.29-1.25 (m, 3H).<\/p>\n

The synthetic route of 131797-35-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 131797-35-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[220,131],"tags":[126],"class_list":["post-3359","post","type-post","status-publish","format-standard","hentry","category-131797-35-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nApplication of 5-Chloro-3-(trifluoromethyl)-1H-pyrazole<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 131797-35-8, name is 5-Chloro-3-(trifluoromethyl)-1H-pyrazole, A new synthetic method of this compound is introduced below., Product Details of 131797-35-8\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3359\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Application of 5-Chloro-3-(trifluoromethyl)-1H-pyrazole\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Application of 5-Chloro-3-(trifluoromethyl)-1H-pyrazole","description":"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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