{"id":3358,"date":"2021-04-13T00:00:00","date_gmt":"2021-04-12T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3358"},"modified":"2021-04-13T00:00:00","modified_gmt":"2021-04-12T16:00:00","slug":"discovery-of-5-furan-2-yl-1h-pyrazol-3-amine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3358","title":{"rendered":"Discovery of 5-(Furan-2-yl)-1H-pyrazol-3-amine"},"content":{"rendered":"

Electric Literature of 96799-02-9<\/a>,Some common heterocyclic compound, 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, molecular formula is C7H7N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

To a solution of cyanuric chloride (300 mg, 1.63 mmol) in THF (16 mL) was added thiophenol (0.17 mL, 1.63 mmol) and DIPEA (0.28 mL, 1.63 mmol) at 0 C. The reaction mixture was stirred at 0 0C to room temperature for 2 hours. After starting material was consumed, 3-amino-3(2-furyl)pyrazole (243 mg, 1.63 mmol) and DIPEA (0.28 mL, 1.63 mmol) was added at O C. The mixture was stirred at room temperature for 3 additional hours. 1-methylpiperazine (0.27 mL, 2.45 mmol) and DlPEA (0.43 mL, 2.45 mmol) were added to the above mixture and allowed to stir at room temperature for overnight. Saturated NaHCC>;3 in water was added and the mixture was extracted by ethyl acetate. The combined organic was washed by brine, dried over sodium sulfate and concentrated. The residue was chromatographed on a silica gel column eluted with 0-5 % MeOH\/DCM to afford compound 9 as light yellow solid (100 mg, 14 %). IH NMR (400 MHz, DMSO-d6) delta 12.69 (bs, IH, NH), 9.79 (s, IH, NH), 7.79 (bs, I H, NH), 7.61 (bs, 2H, Ar-H), 7.45 (s, 3H, Ar-H), 6.60 (s-lH, Ar-H), 5.98 (bs,lH, Ar-H), 3.70 (bs, 4H, 2CH2), 2.31 (bs, 4H, 2CH2), 2.18 (s, 3H,CH3); ESl -MS: calculated for (C2,H22N80S) 434, found 435 [M+H]+. HPLC: retention time: 18.68 min. purity: 99%.<\/p>\n

The synthetic route of 96799-02-9 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 96799-02-9 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[334,131],"tags":[126],"class_list":["post-3358","post","type-post","status-publish","format-standard","hentry","category-96799-02-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nDiscovery of 5-(Furan-2-yl)-1H-pyrazol-3-amine<\/title>\n<meta name=\"description\" content=\"Electric Literature of 96799-02-9,Some common heterocyclic compound, 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, molecular formula is C7H7N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3358\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Discovery of 5-(Furan-2-yl)-1H-pyrazol-3-amine\" \/>\n<meta property=\"og:description\" content=\"Electric Literature of 96799-02-9,Some common heterocyclic compound, 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, molecular formula is C7H7N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3358\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-12T16:00:00+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3358\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3358\",\"name\":\"Discovery of 5-(Furan-2-yl)-1H-pyrazol-3-amine\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-04-12T16:00:00+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Electric Literature of 96799-02-9,Some common heterocyclic compound, 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, molecular formula is C7H7N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3358#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=3358\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3358#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Discovery of 5-(Furan-2-yl)-1H-pyrazol-3-amine\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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