{"id":3264,"date":"2021-04-09T00:00:00","date_gmt":"2021-04-08T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3264"},"modified":"2021-04-09T00:00:00","modified_gmt":"2021-04-08T16:00:00","slug":"a-new-synthetic-route-of-135-trimethyl-1h-pyrazole-4-carbaldehyde","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3264","title":{"rendered":"A new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde"},"content":{"rendered":"

Reference of 2644-93-1<\/a>, These common heterocyclic compound, 2644-93-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

At room temperature for 6-bromo-4-chloro-2-methoxy-3 – (4 – (trifluoromethyl) benzyl) quinoline (1.37 g, 3.86 mmol, Intermediate 10: step d) comprises that the flask, THF It was added (45 mL) to obtain a colorless, homogeneous mixture.Cooling the solution to -78 Next,ndropwise -BuLi (2.5 M, 1.8 mL, 4.5 mmol in hexane).The color of the solution was reddish brown.4 minutes after, 1,3,5-trimethyl -1H-pyrazole-4-carbaldehyde (300 mg, 2.17 mmol, 3 mL of THF) was introduced to he a mixture of red-brown color over 5 min It was in turn greenish yellow.The mixture was warmed to 0 over 45 minutes and, at this time the reaction NH4was quenched with aqueous solution of Cl.The mixture was diluted further with water and extracted with EtOAc (3 \u00a1\u00c1 150 mL).The combined organics were washed with brine, MgSO4dried, filtered, and concentrated to give a light orange foam.Silica gel by FCC on (2% MeOH-DCM, increased to 8% MeOH-DCM), to give the title compound as a pale yellow non-crystalline solid.<\/p>\n

The synthetic route of 2644-93-1 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 2644-93-1 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[391,131],"tags":[126],"class_list":["post-3264","post","type-post","status-publish","format-standard","hentry","category-2644-93-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nA new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde<\/title>\n<meta name=\"description\" content=\"Reference of 2644-93-1, These common heterocyclic compound, 2644-93-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3264\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde\" \/>\n<meta property=\"og:description\" content=\"Reference of 2644-93-1, These common heterocyclic compound, 2644-93-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3264\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-08T16:00:00+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3264\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3264\",\"name\":\"A new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-04-08T16:00:00+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Reference of 2644-93-1, These common heterocyclic compound, 2644-93-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3264#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=3264\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3264#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"A new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde","description":"Reference of 2644-93-1, These common heterocyclic compound, 2644-93-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=3264","og_locale":"en_US","og_type":"article","og_title":"A new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde","og_description":"Reference of 2644-93-1, These common heterocyclic compound, 2644-93-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=3264","og_site_name":"pyrazoles-derivatives","article_published_time":"2021-04-08T16:00:00+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=3264","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=3264","name":"A new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2021-04-08T16:00:00+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Reference of 2644-93-1, These common heterocyclic compound, 2644-93-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=3264#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=3264"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=3264#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"A new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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