{"id":3252,"date":"2021-04-09T00:00:00","date_gmt":"2021-04-08T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3252"},"modified":"2021-04-09T00:00:00","modified_gmt":"2021-04-08T16:00:00","slug":"the-important-role-of-5-amino-1h-pyrazole-3-acetic-acid","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3252","title":{"rendered":"The important role of 5-Amino-1H-pyrazole-3-acetic acid"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 174891-10-2, name is 5-Amino-1H-pyrazole-3-acetic acid, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Amino-1H-pyrazole-3-acetic acid<\/a><\/p>\n

Preparation of (3-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-1H-pyrazol-5-yl)acetic acid 4-Chloro-7-(3-chloropropoxy)quinazoline was added to 1 molar equivalent of a solution of (3-amino-1H-pyrazol-5-yl)acetic acid in N-methylpyrrolidinone (NMP) and then left for a period of 12 hours. Crystallisation of the product was observed to occur with and without seeding and with and without the addition of acetonitrile as an anti-solvent. The resultant solid was isolated by filtration, washed with N-methylpyrrolidinone and acetonitrile and then dried in vacuo to yield (3-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-1H-pyrazol-5-yl)acetic acid.hydrochloride as an off-white solid containing one molar equivalent of NMP: 1H-NMR (DMSO d6): 8.92 (s, 1H), 8.79 (d, 1H), 7.45 (pr of d, 1H), 7.38 (d, 1H), 6.7 (s, 1H), 6.67 (s, 1H), 4.31 (t, 2H), 3.85 (t, 2H), 3.72 (s, 2H), 3.3 (t), 2.7 (s,), 2.27 (m, 2H), 2.18 (t), 1.9 (m):MS (+ve ESI): 362.1015 (M+H)+.<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[350,131],"tags":[126],"class_list":["post-3252","post","type-post","status-publish","format-standard","hentry","category-174891-10-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 5-Amino-1H-pyrazole-3-acetic acid<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 174891-10-2, name is 5-Amino-1H-pyrazole-3-acetic acid, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Amino-1H-pyrazole-3-acetic acid\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3252\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 5-Amino-1H-pyrazole-3-acetic acid\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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