{"id":3247,"date":"2021-04-09T00:00:00","date_gmt":"2021-04-08T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3247"},"modified":"2021-04-09T00:00:00","modified_gmt":"2021-04-08T16:00:00","slug":"analyzing-the-synthesis-route-of-methyl-5-hydroxy-1-methyl-1h-pyrazole-3-carboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3247","title":{"rendered":"Analyzing the synthesis route of Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C6H8N2O3<\/a><\/p>\n

(A)Methyl 5-(benzyloxy)-1-methyl-1H-pyrazole-3-carboxylateA mixture of methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate (10.0 g, 64.0 mmol), benzyl bromide (12.0 g, 70 mmol) and potassium carbonate (13.8 g, 100 mmol) in N,N-dimethylformamide (150 mL) was stirred at 50\u00a1\u00e3 C. for 16 h.Water was added to the reaction solution, and the mixture was extracted with ethyl acetate.The organic layer was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to purify the residue by NH-silica gel column chromatography (hexane\/ethyl acetate 90:10 to 50:50).Solvent was removed to obtain a solid (15.8 g, quant.).1H NMR (300 MHz, CDCl3) delta ppm 3.72 (s, 3H), 3.89 (s, 3H), 5.10 (s, 2H), 6.12 (s, 1H), 7.31-7.48 (m, 5H).<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[293,131],"tags":[126],"class_list":["post-3247","post","type-post","status-publish","format-standard","hentry","category-51985-95-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nAnalyzing the synthesis route of Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C6H8N2O3\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3247\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analyzing the synthesis route of Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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