{"id":3211,"date":"2021-04-08T00:00:00","date_gmt":"2021-04-07T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3211"},"modified":"2021-04-08T00:00:00","modified_gmt":"2021-04-07T16:00:00","slug":"introduction-of-a-new-synthetic-route-about-35-dimethyl-4-nitro-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3211","title":{"rendered":"Introduction of a new synthetic route about 3,5-Dimethyl-4-nitro-1H-pyrazole"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14531-55-6 as follows. Safety of 3,5-Dimethyl-4-nitro-1H-pyrazole<\/a><\/p>\n

To a solution of 3,5-dimethyl-4-nitro-1H-pyrazole (2.5 g, 17.7 mmol) and caesium carbonate (6.06 g, 18.6 mmol) in DMF (50 mL) was added 2-bromoethyl methyl ether (2.59 g, 1.75 mL, 18.6 mmol). The mixture was heated at 100 C for 3.5 h. After cooling to room temperature, the mixture was poured into water and extracted with ethyl acetate (3x 50 mL).The combined organic layers were washed with brine (50 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (EtOAc\/heptanes = 1\/4 v\/v%) to afford 1- (2-methoxyethyl) -3,5 -dimethyl-4- nitro-pyrazole (2.66 g, 75.4%) as a white crystalline solid.<\/p>\n

According to the analysis of related databases, 14531-55-6, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 14531-55-6, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[236,131],"tags":[126],"class_list":["post-3211","post","type-post","status-publish","format-standard","hentry","category-14531-55-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about 3,5-Dimethyl-4-nitro-1H-pyrazole<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14531-55-6 as follows. Safety of 3,5-Dimethyl-4-nitro-1H-pyrazole\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3211\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Introduction of a new synthetic route about 3,5-Dimethyl-4-nitro-1H-pyrazole\" \/>\n<meta property=\"og:description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14531-55-6 as follows. 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