{"id":3181,"date":"2021-04-07T00:00:00","date_gmt":"2021-04-06T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3181"},"modified":"2021-04-07T00:00:00","modified_gmt":"2021-04-06T16:00:00","slug":"analyzing-the-synthesis-route-of-1-tert-butyl-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3181","title":{"rendered":"Analyzing the synthesis route of 1-(tert-Butyl)-1H-pyrazole"},"content":{"rendered":"

Reference of 15754-60-6<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15754-60-6 as follows.<\/p>\n

Intermediate 10: 4-Bromo-1-(1,1-dimethylethyl)-1H-pyrazole[0393]1-(1,1-dimethylethyl)-1H-pyrazole (6.1 g, 49.1 mmol) in dichloromethane (DCM) (200 ml) was added N-bromosuccinimde (8.74 g, 49.1 mmol). This was warmed to ambient temperature and stirred for 18 h. There was no starting material present and so the reaction mixture was quenched with aqueous sodium thiosulfate. The organics were washed with water (2\u00a1\u00c1500 ml) and passed through a hydrophobic frit. The filtrate was concentrated in vacuo to yield an orange-brown oil which turned purple on standing (7.402 g).[0395]LCMS (Method B): Rt=1.03 min, MH+=203, 205<\/p>\n

According to the analysis of related databases, 15754-60-6, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 15754-60-6, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[512,131],"tags":[126],"class_list":["post-3181","post","type-post","status-publish","format-standard","hentry","category-15754-60-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nAnalyzing the synthesis route of 1-(tert-Butyl)-1H-pyrazole<\/title>\n<meta name=\"description\" content=\"Reference of 15754-60-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15754-60-6 as follows.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=3181\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analyzing the synthesis route of 1-(tert-Butyl)-1H-pyrazole\" \/>\n<meta property=\"og:description\" content=\"Reference of 15754-60-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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