{"id":3169,"date":"2021-04-07T00:00:00","date_gmt":"2021-04-06T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3169"},"modified":"2021-04-07T00:00:00","modified_gmt":"2021-04-06T16:00:00","slug":"brief-introduction-of-nn-dimethyl-1h-pyrazole-1-sulfonamide","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3169","title":{"rendered":"Brief introduction of N,N-Dimethyl-1H-pyrazole-1-sulfonamide"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 133228-21-4, name is N,N-Dimethyl-1H-pyrazole-1-sulfonamide, This compound has unique chemical properties. The synthetic route is as follows., name: N,N-Dimethyl-1H-pyrazole-1-sulfonamide<\/a><\/p>\n

To a solution [OF N-DIMETHYLSULFAMOYLPYRAZOLE] (44.0 g, 0.251 mol) in dry tetrahydrofuran (500 mL) at-78 C was added dropwise a solution of n-butyllithium (2.5 M in hexane, 105.5 mL, 0.264 mol) while maintaining the temperature [BELOW-60 C.] A thick solid formed during the addition. Upon completion of the addition the reaction mixture was maintained for an additional 15 minutes, after which time a solution of 1,2-dibromo- tetrachloroethane (90 g, 0.276 mol) in tetrahydrofuran (150 mL) was added dropwise while maintaining the temperature below-70 [C.] The reaction mixture turned a clear orange; stirring was continued for an additional 15 [MINUTES. THE-78 C] bath was removed and the reaction was quenched with water (600 mL). The reaction mixture was extracted with methylene chloride (4x), and the organic extracts were dried over magnesium sulfate and concentrated. The crude product was further purified by chromatography on silica gel using methylene chloride-hexane (50: 50) as eluent to afford the title product as a clear colorless oil (57.04 g). 1H NMR [(CDC13)] [8] 3.07 (d, 6H), 6.44 (m, 1H), 7.62 (m, 1H).<\/p>\n

According to the analysis of related databases, 133228-21-4, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 133228-21-4, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[309,131],"tags":[126],"class_list":["post-3169","post","type-post","status-publish","format-standard","hentry","category-133228-21-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nBrief introduction of N,N-Dimethyl-1H-pyrazole-1-sulfonamide<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 133228-21-4, name is N,N-Dimethyl-1H-pyrazole-1-sulfonamide, This compound has unique chemical properties. 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