{"id":3150,"date":"2021-04-06T00:00:00","date_gmt":"2021-04-05T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3150"},"modified":"2021-04-06T00:00:00","modified_gmt":"2021-04-05T16:00:00","slug":"extended-knowledge-of-1-methyl-1h-pyrazole-3-carboxylic-acid","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3150","title":{"rendered":"Extended knowledge of 1-Methyl-1H-pyrazole-3-carboxylic acid"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., Formula: C5H6N2O2<\/a><\/p>\n

Example 1652-(4′-(3-((3S,5R)-3,5-Dimethylpiperazin-l-yl)propyl)biphenyl-3-yloxy)-5-fluoro-N-((ls,4s)-4-(l-methyl-lH-pyrazole-3-carboxamido)cyclohexyl)nicotinamide To a suspension of N-((ls,4s)-4-aminocyclohexyl)-2-(4′-(3-((3S,5R)-3,5-dimethylpiperazin-l- yl)propyl)biphenyl-3-yloxy)-5-fluoronicotinamide (150 mg, 0.24 mmol) in acetonitrile (4 mL) was added 1 -methyl- lH-pyrazole-3-carboxylic acid (37 mg, 0.30 mmol) and triethylamine (0.330 mL, 2.37 mmol). 1-Propanephosphonic acid cyclic anhydride, 1.57M solution in THF (0.189 mL, 0.30 mmol) was then added and the mixture stirred at RT for 2 hours. The mixture was evaporated to dryness and the residue dissolved in DCM (100 ml) and washed with saturated NaHCC^aq), brine, dried (MgSC^) and evaporated to give a foam. This was purified by HPLC to give the title compound as a white solid. Yield: 84 mg 1H NMR (400 MHz, CD3OD) delta 8.46 (d, J= 7.5 Hz, IH), 8.12 (d, J= 3.1 Hz, IH), 8.08 – 8.04 (m, IH), 7.58 – 7.56 (m, IH), 7.54 – 7.50 (m, 2H), 7.48 – 7.45 (m, 2H), 7.41 – 7.38 (m, IH), 7.26 – 7.23 (m, 2H), 7.17 – 7.12 (m,lH), 6.65 (d, J= 2.3 Hz, IH), 4.16 – 4.08 (m, IH), 4.00 – 3.90 (m, IH), 3.84 (s, 3H), 3.58 – 3.46 (m, 4H), 2.95 – 2.87 (m, 2H), 2.71 (t, J= 7.6 Hz, 2H), 2.57 (t, J= 12.8 Hz, 2H), 2.05 – 1.94 (m, 2H), 1.91 – 1.77 (m, 6H), 1.74 – 1.62 (m, 2H), 1.33 (d, J= 6.7 Hz, 6H). MS: [M+H]+=668 (calc=668) (MultiMode+)<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[242,131],"tags":[126],"class_list":["post-3150","post","type-post","status-publish","format-standard","hentry","category-25016-20-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtended knowledge of 1-Methyl-1H-pyrazole-3-carboxylic acid<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., Formula: C5H6N2O2\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3150\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Extended knowledge of 1-Methyl-1H-pyrazole-3-carboxylic acid\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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