{"id":3137,"date":"2021-04-06T00:00:00","date_gmt":"2021-04-05T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3137"},"modified":"2021-04-06T00:00:00","modified_gmt":"2021-04-05T16:00:00","slug":"sources-of-common-compounds-4-bromo-1h-pyrazole-5-carbonitrile","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3137","title":{"rendered":"Sources of common compounds: 4-Bromo-1H-pyrazole-5-carbonitrile"},"content":{"rendered":"

These common heterocyclic compound, 288246-16-2, name is 4-Bromo-1H-pyrazole-5-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C4H2BrN3<\/a><\/p>\n

was prepared: to a solution of Bis-CFhCI PF1022a in acetonitrile (4.8 ml_, 0.02M) was 4-bromo-1 H-pyrazole-3-carbonitrile added (66 mg, 0.38 mmol), potassium bicarbonate (38 mg, 0.38 mmol) and potassium iodide (95 mg, 0.57 mmol). The mixture was heated to 50C for 48 hours. After cooling to room temperature, the solvent was removed under reduced pressure and the residue partitioned between water and DCM. The organics were separated, dried over MgS04 and evaporated. The crude material was purified by reverse phase HPLC to give the title product as a white solid (46 mg).<\/p>\n

The synthetic route of 4-Bromo-1H-pyrazole-5-carbonitrile has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 4-Bromo-1H-pyrazole-5-carbonitrile has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[465,131],"tags":[126],"class_list":["post-3137","post","type-post","status-publish","format-standard","hentry","category-288246-16-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSources of common compounds: 4-Bromo-1H-pyrazole-5-carbonitrile<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 288246-16-2, name is 4-Bromo-1H-pyrazole-5-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C4H2BrN3\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3137\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sources of common compounds: 4-Bromo-1H-pyrazole-5-carbonitrile\" \/>\n<meta property=\"og:description\" content=\"These common heterocyclic compound, 288246-16-2, name is 4-Bromo-1H-pyrazole-5-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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