{"id":3136,"date":"2021-04-06T00:00:00","date_gmt":"2021-04-05T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3136"},"modified":"2021-04-06T00:00:00","modified_gmt":"2021-04-05T16:00:00","slug":"new-learning-discoveries-about-5-isopropyl-1h-pyrazole-3-carboxylic-acid","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3136","title":{"rendered":"New learning discoveries about 5-Isopropyl-1H-pyrazole-3-carboxylic acid"},"content":{"rendered":"

Related Products of 92933-47-6<\/a>, These common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

Step 3 N-(1-(3-isopropyl-1H-pyrazole-5-carbonyl)-3-metbyipyrrolidin-3-yJ)cyclopropanecarboxamideTo a solution of 3-isopropyl-1H-pyrazole-5-carboxylic acid (431 mg, 2.79 mmol) in DMF (6 mL) were added HATU (1.38 g, 3.63 mmol) and DIEA (1.85 mL, 11.18 mmol) and then stirred at room temperature for 5 minutes before the addition of N-(3 -methylpyrrolidin-3-yl)cyclopropane carboxamide hydrochloride (572 mg, 2.79 mmol) was added. The resulting mixture was stirred at room temperature for 16 hrs. The reaction mixture was filtered and the crude product was purifiedby preparative HPLC (Gemini C18, 150 x 25 mm xlO jam, 26-56% MeCN\/H20) to give the desiredproduct (210 mg, 25% yield) as white solid. ?H NMR (400 MHz, DMSO-d6) 6 8.09 (s, IH), 6.41(s, IH), 4.17 – 4.14 (m, 0.SH), 3.88-3.72 (m, 2H), 3.55 -3.52 (m, 1H), 3.38 – 3.35 (m, 0.SH), 2,96-2.93 (m, IH), 2,31 -2.19 (m, 1H), 1.88- 1.72 (m, IH), 1.56- 1.53 (m, 111), 1.38 (s, 3H), 1.22(d, J 7.2 Hz, 6H), 0.63 -0.57 (m, 4H). LCMS (ESI) mlz: 305,1 [M+HJ, RT 0.904 mm(LCMS Method E).<\/p>\n

The synthetic route of 92933-47-6 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 92933-47-6 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[352,131],"tags":[126],"class_list":["post-3136","post","type-post","status-publish","format-standard","hentry","category-92933-47-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nNew learning discoveries about 5-Isopropyl-1H-pyrazole-3-carboxylic acid<\/title>\n<meta name=\"description\" content=\"Related Products of 92933-47-6, These common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3136\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New learning discoveries about 5-Isopropyl-1H-pyrazole-3-carboxylic acid\" \/>\n<meta property=\"og:description\" content=\"Related Products of 92933-47-6, These common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3136\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-05T16:00:00+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3136\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3136\",\"name\":\"New learning discoveries about 5-Isopropyl-1H-pyrazole-3-carboxylic acid\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-04-05T16:00:00+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Related Products of 92933-47-6, These common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3136#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=3136\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3136#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"New learning discoveries about 5-Isopropyl-1H-pyrazole-3-carboxylic acid\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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