{"id":3134,"date":"2021-04-06T00:00:00","date_gmt":"2021-04-05T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3134"},"modified":"2021-04-06T00:00:00","modified_gmt":"2021-04-05T16:00:00","slug":"share-a-compound-3-ethyl-1-methyl-1h-pyrazole-5-carboxylic-acid","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3134","title":{"rendered":"Share a compound : 3-Ethyl-1-methyl-1H-pyrazole-5-carboxylic acid"},"content":{"rendered":"

Some common heterocyclic compound, 26308-42-9, name is 3-Ethyl-1-methyl-1H-pyrazole-5-carboxylic acid, molecular formula is C7H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 26308-42-9<\/a><\/p>\n

General procedure: Pyrazole acid 9a-k (3 mmol) and thionyl chloride (7.5 mmol)were successively added to 20 mL 1,2-dichloroethane, the mixturewere stirred under reflux for 3 h and then concentrated underreduced pressure, the crude products were added in drops into asolution of 5?a-f (5a-h) (3 mmol) and trimethylamine (6 mmol) inTHF (15 mL).The reaction mixturewas stirred under the 0 C for thenight. After reaction the mixture was poured in Na2CO3 solutionand aqueous phase was extracted with ethyl acetate (2 20 mL).The combined organic phase was washed with saturated salt water(2 20 mL), dried over anhydrous Na2SO4, and concentrated underreduced pressure and the residue was purified by silica gel columnchromatography.<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 26308-42-9, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 26308-42-9, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[130,131],"tags":[126],"class_list":["post-3134","post","type-post","status-publish","format-standard","hentry","category-26308-42-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nShare a compound : 3-Ethyl-1-methyl-1H-pyrazole-5-carboxylic acid<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 26308-42-9, name is 3-Ethyl-1-methyl-1H-pyrazole-5-carboxylic acid, molecular formula is C7H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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