{"id":2654,"date":"2021-04-01T02:28:57","date_gmt":"2021-03-31T18:28:57","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2654"},"modified":"2021-04-01T02:28:57","modified_gmt":"2021-03-31T18:28:57","slug":"the-absolute-best-science-experiment-for-c19h20n2o2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2654","title":{"rendered":"The Absolute Best Science Experiment for C19H20N2O2"},"content":{"rendered":"

In an article, author is Kuthyala, Sharanya, once mentioned the application of 50-33-9, Name is Phenylbutazone, molecular formula is C19H20N2O2, molecular weight is 308.37, MDL number is MFCD00005500, category is pyrazoles-derivatives. Now introduce a scientific discovery about this category, Recommanded Product: 50-33-9<\/a>.<\/p>\n

Synthesis, Characterization, and Anticancer Studies of Some Pyrazole-Based Hybrid Heteroatomics<\/p>\n

Defined with a dual-mode of action, the hybrid molecule synthesis is an attractive strategy to endure the scientific challenges in drug discovery. Besides worthy development in cancer therapy, it is still a leading cause of death across the globe. Failure in terms of efficacy, selectivity and toxicity, the statistics of a potential drug to concrete the cancer is rather in bleak. In the present study, synthesized hybrid molecules were well characterized by spectroscopy techniques. The single-crystal X-ray crystallography study revealed the monoclinic crystal system of Dimethyl 1,4-dihydro-2,6-dimethyl-4-(3-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-1H-pyrazol-4-yl)pyridine-3,5-dicarboxylate (5 b) with spacegroupC2\/c. MTT assay provided the anticancer property of the compounds Diethyl1,4-dihydro-3,5-dimethyl-4-(3-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-1H-pyrazol-4-yl)pyridine-2,6-dicarboxylate (5 a) and 5-methyl-1-phenyl-4-(4-(4,5-diphenyl-1H-imidazol-2-yl)-1H-pyrazol-3-yl)-1H-pyrazole (6 a) against A549 cell lines with the IC(50)values of 42.79 mu M and 55.13 mu M respectively. The AO-EB staining assay for cell death analysis confirmed the selective action of both5 aand6 a. Further, molecular docking confirmed the effective binding with cyclin-dependent kinase (CDK2) protein, suggesting that the target compounds are remarkable inhibitors in dysregulating the CDK2 protein in cancer cells.<\/p>\n

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 50-33-9, Recommanded Product: 50-33-9<\/a>.<\/p>\n

Reference:
Pyrazole – Wikipedia<\/a>,
,Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 50-33-9, Recommanded Product: 50-33-9<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[502,131],"tags":[167],"class_list":["post-2654","post","type-post","status-publish","format-standard","hentry","category-50-33-9","category-pyrazoles-derivatives","tag-m-w300-400"],"yoast_head":"\nThe Absolute Best Science Experiment for<\/title>\n<meta name=\"description\" content=\"In an article, author is Kuthyala, Sharanya, once mentioned the application of 50-33-9, Name is Phenylbutazone, molecular formula is C19H20N2O2, molecular weight is 308.37, MDL number is MFCD00005500, category is pyrazoles-derivatives. Now introduce a scientific discovery about this category, Recommanded Product: 50-33-9.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2654\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Absolute Best Science Experiment for\" \/>\n<meta property=\"og:description\" content=\"In an article, author is Kuthyala, Sharanya, once mentioned the application of 50-33-9, Name is Phenylbutazone, molecular formula is C19H20N2O2, molecular weight is 308.37, MDL number is MFCD00005500, category is pyrazoles-derivatives. 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