{"id":2642,"date":"2021-03-31T02:36:29","date_gmt":"2021-03-30T18:36:29","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2642"},"modified":"2021-03-31T02:36:29","modified_gmt":"2021-03-30T18:36:29","slug":"new-explortion-of-35-dimethyl-1h-pyrazole-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2642","title":{"rendered":"New explortion of 3,5-Dimethyl-1H-pyrazole"},"content":{"rendered":"<p>In an article, author is Kumar, M. Rajesh, once mentioned the application of 67-51-6, <a href=\"https:\/\/www.ambeed.com\/products\/67-51-6.html\">Category: pyrazoles-derivatives<\/a>, Name is 3,5-Dimethyl-1H-pyrazole, molecular formula is C5H8N2, molecular weight is 96.13, MDL number is MFCD00005243, category is pyrazoles-derivatives. Now introduce a scientific discovery about this category.<\/p>\n<p>p-TSA center dot H2O mediated one-pot, multi-component synthesis of isatin derived imidazoles as dual-purpose drugs against inflammation and cancer<\/p>\n<p>A novel one-pot multicomponent reaction was performed to synthesize different imidazole and benzotriazole (BTA) isatin-based medicinally important compounds using (p-TSA center dot H2O) as an economical and operative acid catalyst. The yield of the products was found to be up to a maximum of 92% when using this catalyst. Antioxidant, anti-breast cancer and anti-inflammatory activities of these 13 isatin-based derivatives (named as 5a-m) were assessed. The inhibitory effects of these compounds were tested in vitro against cyclooxygenase-2 (COX-2, an enzyme responsible for inflammation) and phosphoinositide-3 kinase (PI3K, a key enzyme in breast cancer). Among the 13 isatin-based Imidazole derivatives, five compounds (5a, 5d, 5f, 5 k and 5l) were found to exhibit anti-inflammatory as well as anti-cancer activity, which was validated using HRBC stabilization assay (to show anti-inflammatory activity) and cytotoxicity in MCF-7 (breast cancer cell line) to provide proof for anticancer property of the compounds. The molecular interactions between the two enzymes were probed using molecular docking. Structure-Activity Relationship (SAR) and ADMET prediction results were also useful to screen the most effective imidazole derivatives and to establish them as putative COX-2 inhibitors\/anti-inflammatory drugs. These selected compounds which showed appreciable activity against COX-2 and PI3K are promising drug candidates for the treatment of breast cancer and inflammation which is often associated with breast cancer pathophysiology.<\/p>\n<p>If you are interested in 67-51-6, you can contact me at any time and look forward to more communication. <a href=\"https:\/\/www.ambeed.com\/products\/67-51-6.html\">Category: pyrazoles-derivatives<\/a>.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/>,<a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>If you are interested in 67-51-6, you can contact me at any time and look forward to more communication. <a href=\"https:\/\/www.ambeed.com\/products\/67-51-6.html\">Category: pyrazoles-derivatives<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[249,131],"tags":[145],"class_list":["post-2642","post","type-post","status-publish","format-standard","hentry","category-67-51-6","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New explortion of<\/title>\n<meta name=\"description\" content=\"In an article, author is Kumar, M. Rajesh, once mentioned the application of 67-51-6, Category: pyrazoles-derivatives, Name is 3,5-Dimethyl-1H-pyrazole, molecular formula is C5H8N2, molecular weight is 96.13, MDL number is MFCD00005243, category is pyrazoles-derivatives. Now introduce a scientific discovery about this category.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=2642\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New explortion of\" \/>\n<meta property=\"og:description\" content=\"In an article, author is Kumar, M. Rajesh, once mentioned the application of 67-51-6, Category: pyrazoles-derivatives, Name is 3,5-Dimethyl-1H-pyrazole, molecular formula is C5H8N2, molecular weight is 96.13, MDL number is MFCD00005243, category is pyrazoles-derivatives. 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