{"id":2634,"date":"2021-03-31T02:36:29","date_gmt":"2021-03-30T18:36:29","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2634"},"modified":"2021-03-31T02:36:29","modified_gmt":"2021-03-30T18:36:29","slug":"extracurricular-laboratory-discover-of-3-amino-5-4-phenoxyphenylpyrazole-4-carbonitrile","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2634","title":{"rendered":"Extracurricular laboratory: Discover of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile"},"content":{"rendered":"

Chemistry can be defined as the study of matter and the changes it undergoes. You\u00a1\u00afll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 330792-70-6, Name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, molecular formula is , belongs to pyrazoles-derivatives compound. In a document, author is Ismail, Magda M. F., Quality Control of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile<\/a>.<\/p>\n

Synthesis of new arylazopyrazoles as apoptosis inducers: Candidates to inhibit proliferation of MCF-7 cells<\/p>\n

New 4-arylazo-3,5-diamino-1H-pyrazole derivatives substituted in the 4-aryl ring with the acetyl moiety were designed and synthesized. The antiproliferative activity of the novel arylazopyrazoles was examined against the MCF-7 cell line. Among all target compounds,8b(IC(50)3.0 mu M) and8f(IC(50)4.0 mu M) displayed higher cytotoxicity as compared with the reference standard imatinib (IC(50)7.0 mu M). Further studies to explore the mechanism of action were performed on the most active hit of our library,8b, via anti-CDK2 kinase activity. It demonstrated good inhibitory effects for CDK2 (IC(50)0.24 mu M) with 62.5% inhibition, compared with imatinib. The cell cycle analysis in the MCF-7 cell line revealed apoptosis induction by8band cell cycle arrest at the S phase. Docking in the CDK2 active site and pharmacophore modeling confirmed the affinity of8bto the CDK2 active site. Absorption, distribution, metabolism, and excretion studies revealed that our target compounds are orally bioavailable, with no permeation through the blood-brain barrier.<\/p>\n

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 330792-70-6, in my other articles. Quality Control of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile<\/a>.<\/p>\n

Reference:
Pyrazole – Wikipedia<\/a>,
,Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 330792-70-6, in my other articles. Quality Control of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[192,131],"tags":[127],"class_list":["post-2634","post","type-post","status-publish","format-standard","hentry","category-330792-70-6","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nExtracurricular laboratory: Discover of<\/title>\n<meta name=\"description\" content=\"Chemistry can be defined as the study of matter and the changes it undergoes. 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