{"id":2616,"date":"2021-03-31T02:35:19","date_gmt":"2021-03-30T18:35:19","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2616"},"modified":"2021-03-31T02:35:19","modified_gmt":"2021-03-30T18:35:19","slug":"the-absolute-best-science-experiment-for-5932-27-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2616","title":{"rendered":"The Absolute Best Science Experiment for 5932-27-4"},"content":{"rendered":"

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 5932-27-4, Name is Ethyl 1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O2. In an article, author is Abdellatif, Khaled R. A.,once mentioned of 5932-27-4, Name: Ethyl 1H-pyrazole-3-carboxylate<\/a>.<\/p>\n

Synthesis of novel halogenated triarylpyrazoles as selective COX-2 inhibitors: Anti-inflammatory activity, histopatholgical profile and in-silico studies<\/p>\n

A novel series of halogenated triarylpyrazoles 12a-l was designed and synthesized. All target compounds showed good in vitro COX-2 inhibitory activity (IC50 = 0.043-0.17 mu M) over COX-1 (IC50 = 7.8 – 15.4 mu M) relative to celecoxib (COX-1\/IC50 = 9.87, COX-2\/IC50 = 0.055), with acceptable selectivity index values (SI = 50.6-253.1). Also, they displayed moderate to potent in vivo anti-inflammatory activity (% edema inhibition = 16.9-87.9) comparable to celecoxib (% edema inhibition = 46.6-72.1) as standard drug. Three fluorinated pyrazoles 12a, 12g and 12j, exhibited superior anti-inflammatory activity at all time intervals (% edema inhibition = 42.1-87.9) with better gastric profile (UI = 1.25-2.5) than the traditional NSAID; indomethacin (UI = 14) and were close to the selective COX-2 inhibitor; celecoxib (UI = 1.75). In-silico docking and ADME studies of 12a, 12g and 12j supported the obtained biological data and pointed out their potential use for the development of bio-available, safe and potent anti-inflammatory drugs.<\/p>\n

Interested yet? Keep reading other articles of 5932-27-4, you can contact me at any time and look forward to more communication. Name: Ethyl 1H-pyrazole-3-carboxylate<\/a>.<\/p>\n

Reference:
Pyrazole – Wikipedia<\/a>,
,Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Interested yet? Keep reading other articles of 5932-27-4, you can contact me at any time and look forward to more communication. Name: Ethyl 1H-pyrazole-3-carboxylate<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[170,131],"tags":[126],"class_list":["post-2616","post","type-post","status-publish","format-standard","hentry","category-5932-27-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe Absolute Best Science Experiment for<\/title>\n<meta name=\"description\" content=\"Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 5932-27-4, Name is Ethyl 1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O2. In an article, author is Abdellatif, Khaled R. 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