{"id":2397,"date":"2021-03-19T06:39:17","date_gmt":"2021-03-18T22:39:17","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2397"},"modified":"2021-03-19T06:39:17","modified_gmt":"2021-03-18T22:39:17","slug":"brief-introduction-of-1072-97-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2397","title":{"rendered":"Brief introduction of 1072-97-5"},"content":{"rendered":"

In an article, author is Du, Pan, once mentioned the application of 1072-97-5, Name is 5-Bromopyridin-2-amine, molecular formula is C5H5BrN2, molecular weight is 173.01, MDL number is MFCD00006323, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Recommanded Product: 1072-97-5<\/a>.<\/p>\n

Comparative DFT study of metal-free Lewis acid-catalyzed C-H and N-H silylation of (hetero)arenes: mechanistic studies and expansion of catalyst and substrate scope<\/p>\n

Direct selective dehydrogenative silylation of thiophenes, pyridines, indoles and anilines to synthesize silyl-substituted aromatic compounds catalyzed by metal-free Lewis acids was achieved recently. However, there is still insufficient mechanistic data for these transformations. Using density functional theory calculations, we conducted a detailed investigation of the mechanism of the B(C6F5)(3)-catalyzed dehydrogenative silylation of N-methylindole, N,N-dimethylaniline and N-methylaniline. We successfully located the most favourable reaction pathways that can explain the experimental observations notably well. The most favourable pathway for B(C6F5)(3)-catalyzed C-H silylation of N-methylindole includes nucleophilic attack, proton abstraction and hydride migration. The C-H silylation of N,N-dimethylaniline follows a similar pathway to N-methylindole rather than that proposed by Hou’s group. Our mechanism successfully explains that the transformations of N-methylindoline to N-methylindole produce different products at different temperatures. For N-methylaniline bearing both N-H and para-phenyl C-H bonds, the N-H silylation reaction is more facile than the C-H silylation reaction. Our proposed mechanism of N-H silylation of N-methylaniline is different from that proposed by the groups of Paradies and Stephan. Lewis acids Al(C6F5)(3), Ga(C6F5)(3) and B(2,6-Cl2C6H3)(p-HC6F4)(2) can also catalyze the C-H silylation of N-methylindole like B(C6F5)(3), but the most favourable pathways are those promoted by N-methylindoline. Furthermore, we also found several other types of substrates that would undergo C-H or N-H silylation reactions under moderate conditions. These findings may facilitate the design of new catalysts for the dehydrogenative silylation of inactivated (hetero)arenes.<\/p>\n

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 1072-97-5, Recommanded Product: 1072-97-5<\/a>.<\/p>\n

Reference:
Pyridine – Wikipedia<\/a>,
,Pyridine | C5H5N – PubChem<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 1072-97-5, Recommanded Product: 1072-97-5<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[491,482],"tags":[126],"class_list":["post-2397","post","type-post","status-publish","format-standard","hentry","category-1072-97-5","category-pyridine-derivatives","tag-m-w100-200"],"yoast_head":"\nBrief introduction of<\/title>\n<meta name=\"description\" content=\"In an article, author is Du, Pan, once mentioned the application of 1072-97-5, Name is 5-Bromopyridin-2-amine, molecular formula is C5H5BrN2, molecular weight is 173.01, MDL number is MFCD00006323, category is pyridine-derivatives. 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