{"id":2378,"date":"2021-03-18T02:56:30","date_gmt":"2021-03-17T18:56:30","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2378"},"modified":"2021-03-18T02:56:30","modified_gmt":"2021-03-17T18:56:30","slug":"introduction-of-a-new-synthetic-route-about-84547-84-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2378","title":{"rendered":"Introduction of a new synthetic route about 84547-84-2"},"content":{"rendered":"

84547-84-2, name is 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C5H5BrN2O2<\/a><\/p>\n

To a solution of N-methyl-4-bromopyrazole-3-carboxylic acid (2.0 g), available from step A, in 65 mL of anhydrous DMF was added bromotripyrrolidinophosphonium hexafluorophosphate (PyBrop, 4.60 g), dimethyl amine (10 mL, 2.0 M in THF) and diisopropylethyl amine (5.2 mL) at 25 C. The mixture was stirred for 26 h, and concentrated under reduced pressure to an oily residue. This residue was treated with a 1.0 M NaOH aqueous solution, and extracted with ethyl acetate (50 mL x 4). The organic extracts were combined, washed with brine, and dried with anhydrous Na2SO4. Removal of solvents yielded an oil, which was purified by preparative thin layer chromatography, eluting with CH2CI2-MeOH (20: 1), to give 1.09 g of the amide product (48%, MH+ = 232.0).<\/p>\n

The synthetic route of 84547-84-2 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 84547-84-2 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[479,131],"tags":[127],"class_list":["post-2378","post","type-post","status-publish","format-standard","hentry","category-84547-84-2","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nIntroduction of a new synthetic route about 84547-84-2<\/title>\n<meta name=\"description\" content=\"84547-84-2, name is 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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