{"id":2377,"date":"2021-03-18T02:56:30","date_gmt":"2021-03-17T18:56:30","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2377"},"modified":"2021-03-18T02:56:30","modified_gmt":"2021-03-17T18:56:30","slug":"introduction-of-a-new-synthetic-route-about-99662-34-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2377","title":{"rendered":"Introduction of a new synthetic route about 99662-34-7"},"content":{"rendered":"

Electric Literature of 99662-34-7<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 99662-34-7 name is 4-Pyrazol-1-yl-benzaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

To a cooled solution of 4-(pyrazol-l-yl)benzaldehyde (3.0 g, 0.017 mole) in methanol (20 mL) under N2, was added sodium borohydride (0.79 g, 0.02 mole) in portion wise. The reaction mixture was warmed to RT and stirred for 2 h. The reaction mixture was concentrated under vacuum, dissolved in ice cold water (75 mL) and extracted with ethyl acetate (100 mL x 2). Organic layer was washed with brine solution (50 mL), dried over Na2S04 and concentrated under vacuum to obtain the crude compound which was further purified by flash chromatography using ethyl acetate: n-hexane (40:60) to get l-(4- hydroxymethylphenyl) – 1 H-pyrazole . (0225) Yield: 2.4 g; 1H – NMR (DMSO- 6, 400 MHz) d ppm: 4.52 – 4.53 (d, J = 5.6 Hz, 2H), 5.23 – 5.26 (t, J = 5.7 Hz, 1H), 6.52 (s, 1H), 7.41 – 7.43 (d, J = 8.3 Hz, 2H), 7.72 (s, 1H), 7.77 – 7.79 (d, J = 8.3 Hz, 2H), 8.09 (d, J = 2.3 Hz, 1H); Mass (m\/z): 175.1 (M+H)+.<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Pyrazol-1-yl-benzaldehyde, and friends who are interested can also refer to it.<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Pyrazol-1-yl-benzaldehyde, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[478,131],"tags":[126],"class_list":["post-2377","post","type-post","status-publish","format-standard","hentry","category-99662-34-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about 99662-34-7<\/title>\n<meta name=\"description\" content=\"Electric Literature of 99662-34-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 99662-34-7 name is 4-Pyrazol-1-yl-benzaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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The downstream synthesis method of this compound is introduced below.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=2377","og_locale":"en_US","og_type":"article","og_title":"Introduction of a new synthetic route about 99662-34-7","og_description":"Electric Literature of 99662-34-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 99662-34-7 name is 4-Pyrazol-1-yl-benzaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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