{"id":2361,"date":"2021-03-18T02:55:32","date_gmt":"2021-03-17T18:55:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2361"},"modified":"2021-03-18T02:55:32","modified_gmt":"2021-03-17T18:55:32","slug":"sources-of-common-compounds-79080-39-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2361","title":{"rendered":"Sources of common compounds: 79080-39-0"},"content":{"rendered":"

Synthetic Route of 79080-39-0<\/a>, These common heterocyclic compound, 79080-39-0, name is 1-Methyl-1H-pyrazole-3-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

To 1 -methyl-1 H-pyrazole-3-carbonitrile (2.7 g, 25.2 mmol) in Et20 (150 mL) cooled in ice bath was added LiAIH4 (27.7 mL, 55.5 mmol, 2M in THF) slowly, and the reaction mixture was allowed to warm to room temperature and stirred overnight. The reaction was then cooled in ice bath and quenched by sequential addition of water (4 mL), 15percentNaOH solution (4 mL), and water (12 mL). The mixture was then stirred for 15 minutes, and the resulting solid was filtered. The filtrate was dried over MgS04 and concentrated to afford (1 -methyl- 1 H-pyrazol-3-yl)methanamine (1 .28 g) as a clear oil. LC-MS (ES) m\/z = 1 12 [M+H]+. 1H NMR (400 MHz, DMSO-c\/6): delta 1 .69 (br. s, J = 1 .5 Hz, 2H), 3.60 (s, 2H), 3.75 (s, 3H), 6.12 (d, J = 2.0 Hz, 1 H), 7.53 (d, J = 2.0 Hz, 1 H).<\/p>\n

Statistics shows that 1-Methyl-1H-pyrazole-3-carbonitrile is playing an increasingly important role. we look forward to future research findings about 79080-39-0.<\/p>\n","protected":false},"excerpt":{"rendered":"

Statistics shows that 1-Methyl-1H-pyrazole-3-carbonitrile is playing an increasingly important role. we look forward to future research findings about 79080-39-0.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[424,131],"tags":[126],"class_list":["post-2361","post","type-post","status-publish","format-standard","hentry","category-79080-39-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSources of common compounds: 79080-39-0<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 79080-39-0, These common heterocyclic compound, 79080-39-0, name is 1-Methyl-1H-pyrazole-3-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=2361\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sources of common compounds: 79080-39-0\" \/>\n<meta property=\"og:description\" content=\"Synthetic Route of 79080-39-0, These common heterocyclic compound, 79080-39-0, name is 1-Methyl-1H-pyrazole-3-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=2361\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-17T18:55:32+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=2361\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=2361\",\"name\":\"Sources of common compounds: 79080-39-0\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-03-17T18:55:32+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Synthetic Route of 79080-39-0, These common heterocyclic compound, 79080-39-0, name is 1-Methyl-1H-pyrazole-3-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=2361#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.pyrazoles-derivatives.com\/?p=2361\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=2361#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Sources of common compounds: 79080-39-0\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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