{"id":2358,"date":"2021-03-18T02:55:32","date_gmt":"2021-03-17T18:55:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2358"},"modified":"2021-03-18T02:55:32","modified_gmt":"2021-03-17T18:55:32","slug":"new-downstream-synthetic-route-of-345637-71-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2358","title":{"rendered":"New downstream synthetic route of 345637-71-0"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 345637-71-0, Recommanded Product: 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid<\/a><\/p>\n

Example 17 N-[5-({7-[(1R)-2-Hydroxy-1-methylethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}carbonyl)pyridin-3-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetamide (5-Methyl-3-trifluoromethyl-pyrazol-1-yl)acetic acid (46.8 mg, 0.225 mmol) was added to (R,S) (5-aminopyridin-3-yl){7-[(1R)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}methanone (66 mg, 0.173 mmol) (see Preparation 36), 1-propylphosphonic acid cyclic anhydride (0.31 mL, 0.519 mmol) and DIPEA (0.09 mL, 0.606 mmol) in THF (5 mL). The mixture was heated at reflux for 48 hours, evaporated in vacuo and partitioned between saturated aqueous sodium bicarbonate (5 mL) and ethyl acetate (5 mL). The organic phase was dried over sodium sulfate, evaporated in vacuo and the residue was purified by column chromatography on silica gel (gradient of EtOAc:Hexane 85:15) to afford the intermediate as an off white solid in 53% yield, 52 mg. 10% Hydrochloric acid in 1,4-dioxane (0.4 mL) was added to the intermediate (52 mg, 0.091 mmol) in THF (2 mL) and the mixture was stirred at room temperature for 1.5 hours. The mixture was evaporated in vacuo and triturated with pentane:diethyl ether (3:1, 1 mL) to afford the title compound as an off white solid in 94% yield, 42 mg. 1H NMR (400 MHz, DMSO) delta: 1.49 (d, 3H), 2.32 (d, 3H), 3.56 (m, 1H), 5.00 (m, 1H), 5.20 (s, 2H), 6.56 (s, 1H), 8.45 (s, 1H), 8.54 (s, 1H), 8.79 (s, 1H), 9.02 (s, 2H), 9.48 (s, 1H), 11.05 (s, 1H); LCMS (system 4): Rt=2.86 min; m\/z 488 [M+H]+.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[329,131],"tags":[127],"class_list":["post-2358","post","type-post","status-publish","format-standard","hentry","category-345637-71-0","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nNew downstream synthetic route of 345637-71-0<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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