{"id":2355,"date":"2021-03-18T02:55:32","date_gmt":"2021-03-17T18:55:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2355"},"modified":"2021-03-18T02:55:32","modified_gmt":"2021-03-17T18:55:32","slug":"extended-knowledge-of-1904-31-0-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2355","title":{"rendered":"Extended knowledge of 1904-31-0"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1904-31-0, category: pyrazoles-derivatives<\/a><\/p>\n

2-Bromo-5-(4-methanesulfonyl-phenoxy)-pyridine (0.47 mmol), sodium-tert.-butylate (1.4 eq.), and 1 -methyl-1 H-pyrazole-3-amine (1.2 eq.) are dissolved in degassed dioxane (2.5 ml) and heated to 80 0C. Chloro-5 (di-2-norbornylphosphino)(2-dimethylaminoferrocene-1 -yl)palladium (II) (5.9 mg) in degassed dioxane (1 ml) is added and the reaction mixture is heated for 1 hour at 142 0C in the microwave. The reaction is quenched with ethylacetate (30 ml) and filtrated over celite. The solvent of the filtrate is removed in vacuo. [5-(4-Methanesulfonyl-phenoxy)-pyridine-2-yl]-(1- methyl-1 H-pyrazole-3-yl)-amine (“A27”) is obtained after reversed phase column chromatography (water \/ acetonitrile + 0.1 percent TFA) as orange powder in a yield of 55 percent; HPLC (method C): 1.57 min; LC-MS (method A): 0.787 min, 345.15 (M+H+);1H-NMR (DMSO-d6l 500 MHz): delta [ppm] 9.317 (s, 1H), 8.020 (d, 1 H, J=2.9 Hz), 7.883 {d, 2H, J=8.9 Hz), 7.504 (d, 1 H, J=2.2 Hz), 7.470 (dd, 1 H, J=2.9 Hz, J=9.0 Hz), 7.355 (d, 1 H, J=9.0 Hz), 7.125 (d, 2H, J=8.9 Hz), 6.268 (d, 1 H, J=2.2 Hz), 3.740 (s, 3H), 3.170 (s, 3H).Example 23<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[219,131],"tags":[145],"class_list":["post-2355","post","type-post","status-publish","format-standard","hentry","category-1904-31-0","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nExtended knowledge of 1904-31-0<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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