{"id":2309,"date":"2021-03-17T02:19:45","date_gmt":"2021-03-16T18:19:45","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2309"},"modified":"2021-03-17T02:19:45","modified_gmt":"2021-03-16T18:19:45","slug":"introduction-of-a-new-synthetic-route-about-31108-57-3-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2309","title":{"rendered":"Introduction of a new synthetic route about 31108-57-3"},"content":{"rendered":"

31108-57-3, name is 1H-Pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C4H3N3<\/a><\/p>\n

Prepared according General Procedure E, Step 2 from compound Cll (60 mg, 0.14 mmol) and lH-pyrazole-4-carbonitrile (63 mg, 0.67 mmol), with purification by column chromatography on silica gel to provide compound 27 as an off-white solid (27.3 mg, 44%): mp 176-178 C; 1HNMR (300 MHz, CDCI3) delta 7.83 (d, J = 12.3 Hz, 2H), 4.95 (q, J = 18.3 Hz, 2H), 3.53 (d, J = 9.0 Hz, IH), 3.33 (s, 3H), 3.22 (d, J = 9.0 Hz, IH), 2.59 (t, J = 9.3 Hz, IH), 2.26-1.35 (m, 17H), 1.31-1.08 (m, 9H), 0.66 (s, 3H) ppm; ESI MS m\/z 437 [M+H-H2Of .<\/p>\n

The synthetic route of 31108-57-3 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 31108-57-3 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[326,131],"tags":[145],"class_list":["post-2309","post","type-post","status-publish","format-standard","hentry","category-31108-57-3","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nIntroduction of a new synthetic route about 31108-57-3<\/title>\n<meta name=\"description\" content=\"31108-57-3, name is 1H-Pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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