{"id":2308,"date":"2021-03-17T02:19:45","date_gmt":"2021-03-16T18:19:45","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2308"},"modified":"2021-03-17T02:19:45","modified_gmt":"2021-03-16T18:19:45","slug":"discovery-of-25016-17-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2308","title":{"rendered":"Discovery of 25016-17-5"},"content":{"rendered":"

Application of 25016-17-5<\/a>, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-17-5, name is Methyl 5-methyl-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.<\/p>\n

b) Method for svnthesising the pyrazolecarboxylic acid ED-2b (synthesis method B)ED-5a (2.00 g, 14.3 mmol) in DMF (7 mL) is added dropwise to a suspension of NaH (694 mg, 60 %, 17.4 mmol) in anhydrous DMF (8 mL) while cooling with ice and the mixture is slowly thawed to RT over 1 h. Then isopropyl bromide (2.7 mL, 28.8 mmol) is added and the mixture is stirred for 20 h at RT. The reaction mixture is mixed with a little water, then for saponification aqueous LiOH solution (414 mg in 3 mL H20) is added and the mixture is stirred for 2 h at 40C. The reaction mixture is neutralised with hydrochloric acid, evaporated down to some extent using the rotary evaporator and the residue is purified by preparative RP-MPLC. The product-containing fractions of ED-2b (HPLC-MS: tRet. = 0.00 min; MS (M-H)” = 167) are combined and freeze-dried.<\/p>\n

The chemical industry reduces the impact on the environment during synthesis Methyl 5-methyl-1H-pyrazole-3-carboxylate. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis Methyl 5-methyl-1H-pyrazole-3-carboxylate. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[470,131],"tags":[126],"class_list":["post-2308","post","type-post","status-publish","format-standard","hentry","category-25016-17-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nDiscovery of 25016-17-5<\/title>\n<meta name=\"description\" content=\"Application of 25016-17-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-17-5, name is Methyl 5-methyl-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=2308\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Discovery of 25016-17-5\" \/>\n<meta property=\"og:description\" content=\"Application of 25016-17-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-17-5, name is Methyl 5-methyl-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Discovery of 25016-17-5","description":"Application of 25016-17-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-17-5, name is Methyl 5-methyl-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. 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