{"id":2287,"date":"2021-03-16T02:45:46","date_gmt":"2021-03-15T18:45:46","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2287"},"modified":"2021-03-16T02:45:46","modified_gmt":"2021-03-15T18:45:46","slug":"discovery-of-57999-06-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2287","title":{"rendered":"Discovery of 57999-06-1"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 57999-06-1, name is 4-Phenyl-1H-pyrazol-5-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 57999-06-1, Quality Control of 4-Phenyl-1H-pyrazol-5-amine<\/a><\/p>\n

A solution of enaminone 3a (3.32 g, 0.01 mol) and 4-phenyl-1H-pyrazol-5-amine (8a) (1.74 g, 0.011 mol) in acetic acid was refluxed for-5 min. A precipitate formed after cooling was filtered, washed-with isopropyl alcohol, and dried in vacuo. The yield was 2.99 g (70%). M.p. 193-194 C. 1H NMR (DMSO-d6), delta: 1.32 (t, 3 H,CH3, J = 6.9 Hz); 3.21 (s, 3 H, CH3); 4.01 (q, 2 H, CH2O,J = 6.9 Hz); 6.97 (d, 2 H, H arom, J = 7.4 Hz); 7.25 (t, 1 H, H arom,J = 7.3 Hz); 7.43 (t, 2 H, H arom, J = 7.3 Hz); 7.51 (d, 2 H, H arom,J = 7.4 Hz); 8.15 (d, 2 H, Harom, J = 7.3 Hz); 8.80 (s, 1 H, CH);9.19 (s, 1 H, CH); 10.91 (br.s, 1 H, NH). 13C NMR (DMSO-d6),delta: 14.72, 15.28, 63.24, 109.91, 113.67, 115.09, 119.78, 125.82,126.13, 128.63, 131.74, 132.98, 143.39, 143.46, 147.02, 150.34,154.73, 164.88, 179.12. MS, m\/z (Irel (%)): 428 [M]+ (100), 399 (4),269 (37), 254 (4), 234 (13). Found (%): C, 64.38; H, 4.68;N, 19.63. C23H20N6OS. Calculated (%): C, 64.47; H, 4.70; N, 19.61.<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Phenyl-1H-pyrazol-5-amine, and friends who are interested can also refer to it.<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Phenyl-1H-pyrazol-5-amine, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[347,131],"tags":[126],"class_list":["post-2287","post","type-post","status-publish","format-standard","hentry","category-57999-06-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nDiscovery of 57999-06-1<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 57999-06-1, name is 4-Phenyl-1H-pyrazol-5-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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