{"id":2283,"date":"2021-03-16T02:45:46","date_gmt":"2021-03-15T18:45:46","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2283"},"modified":"2021-03-16T02:45:46","modified_gmt":"2021-03-15T18:45:46","slug":"the-origin-of-a-common-compound-about-36650-74-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2283","title":{"rendered":"The origin of a common compound about 36650-74-5"},"content":{"rendered":"

Synthetic Route of 36650-74-5<\/a>,Some common heterocyclic compound, 36650-74-5, name is 1H-Pyrazole-3-carbonitrile, molecular formula is C4H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

To a suspension of Compound SA (100 mg, 0.25 mmol) in THF (25 niL) was added lH-pyrazole- 3-carbonitrile (70 mg, 0.75 mmol) and K2CO3 ( 103 mg, 0.75mmol). The mixture was stirred at 35C for 15h. Then the reaction mixture was extracted 50 mL EtOAc, washed with 100 111L H20 and 100 mL brine and evaporated in vacuo. The resulting residue was purified by reverse- phase prep-HPLC to afford SA-22 as a white solid ( 23 mg, 0.056mnol, 24 % yield). 1H NMR (500 MHz, CDCI3), delta (ppm), 7.48 (d, IH), 6.73 (d, IH), 5.03(1H,AB), 4.93(1H,AB), 2.60 (t,lH), 1.00-2.25 (24H, m), 0.68 (s, 3H). LCMS: Rt = 2.38 mm, MS (ESI) m\/z: 410.2 [M+H] +<\/p>\n

The synthetic route of 36650-74-5 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 36650-74-5 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[357,131],"tags":[145],"class_list":["post-2283","post","type-post","status-publish","format-standard","hentry","category-36650-74-5","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nThe origin of a common compound about 36650-74-5<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 36650-74-5,Some common heterocyclic compound, 36650-74-5, name is 1H-Pyrazole-3-carbonitrile, molecular formula is C4H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2283\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The origin of a common compound about 36650-74-5\" \/>\n<meta property=\"og:description\" content=\"Synthetic Route of 36650-74-5,Some common heterocyclic compound, 36650-74-5, name is 1H-Pyrazole-3-carbonitrile, molecular formula is C4H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2283\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-15T18:45:46+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2283\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2283\",\"name\":\"The origin of a common compound about 36650-74-5\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-03-15T18:45:46+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Synthetic Route of 36650-74-5,Some common heterocyclic compound, 36650-74-5, name is 1H-Pyrazole-3-carbonitrile, molecular formula is C4H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2283#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=2283\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2283#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The origin of a common compound about 36650-74-5\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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