{"id":2279,"date":"2021-03-16T02:45:46","date_gmt":"2021-03-15T18:45:46","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2279"},"modified":"2021-03-16T02:45:46","modified_gmt":"2021-03-15T18:45:46","slug":"introduction-of-a-new-synthetic-route-about-15366-34-4-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2279","title":{"rendered":"Introduction of a new synthetic route about 15366-34-4"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 15366-34-4, name is Methyl 1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15366-34-4, Recommanded Product: 15366-34-4<\/a><\/p>\n

Methyl 1H-pyrazole-3-carboxylate (0.500 g, 3.96 mmol) was dissolved in dry MeCN (30 mL), then (bromomethyl)cyclopropane (0.46 1 mL, 4.76 mmol) was added,followed by cesium carbonate (1.94 g, 5.95 mmol). The reaction mixture was stirred at 60C for 2 h. The reaction mixture was cooled to rt and diluted with EtOAc. ThenCELITE was added, and the solvent was removed under reduced pressure. The residue was purified by flash chromatography (solid loading on CELITE, 0-55% EtOAc\/Hex) affording two products.Intermediate hA (0.197 g, 28% yield) as a colorless syrup eluted at 20%EtOAc. MS(ESI) m\/z: 180.9 (M+H) ?HNMR: (500 MHz, CDC13) oe ppm 7.49 (d, J1.9 Hz, 1H), 6.84 (d, J=1.9 Hz, 1H), 4.44 (d, J=7.2 Hz, 2H), 3.88 (s, 3H), 1.44 – 1.31 (m,1H), 0.57 – 0.48 (m, 2H), 0.45 – 0.37 (m, 2H).Intermediate 12A (0.4 15 g, 58% yield) as a colorless syrup eluted at 42%EtOAc. MS(ESI) m\/z: 180.9 (M+H) ?H NMR: (500 MHz, CDC13) oe ppm 7.54 (d, J2.5Hz, 1H), 6.84 (d, J=2.5 Hz, 1H), 4.07 (d, J=7.2 Hz, 2H), 3.93 (s, 3H), 1.32 (quint, J7.6,4.9 Hz, 1H), 0.71 – 0.64 (m, 2H), 0.45 – 0.36 (m, 2H).<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[174,131],"tags":[126],"class_list":["post-2279","post","type-post","status-publish","format-standard","hentry","category-15366-34-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about 15366-34-4<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 15366-34-4, name is Methyl 1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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