{"id":2258,"date":"2021-03-16T02:44:44","date_gmt":"2021-03-15T18:44:44","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2258"},"modified":"2021-03-16T02:44:44","modified_gmt":"2021-03-15T18:44:44","slug":"some-tips-on-68703-67-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2258","title":{"rendered":"Some tips on 68703-67-3"},"content":{"rendered":"

Reference of 68703-67-3<\/a>,Some common heterocyclic compound, 68703-67-3, name is 4-Amino-1H-pyrazole-3-carbonitrile, molecular formula is C4H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

To a solution of 4-amino-1H-pyrazole-3-carbonitrile (270 mg, 2.4977 mmol) in DMF was added cyclopropane carboxylic acid (1.1 equiv., 2.7475 mmol), HBTU (1.2 equiv., 2.9972 mmol) and DIEA (10 equiv., 24.977 mmol). Upon reaction completion, the reaction was diluted with saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The organic layer was concentrated in vacuo and purified by flash column chromatography onsilica to give 109a. MS-ESI [M+H] = 177.1.<\/p>\n

The synthetic route of 68703-67-3 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 68703-67-3 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[464,131],"tags":[126],"class_list":["post-2258","post","type-post","status-publish","format-standard","hentry","category-68703-67-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSome tips on 68703-67-3<\/title>\n<meta name=\"description\" content=\"Reference of 68703-67-3,Some common heterocyclic compound, 68703-67-3, name is 4-Amino-1H-pyrazole-3-carbonitrile, molecular formula is C4H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2258\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Some tips on 68703-67-3\" \/>\n<meta property=\"og:description\" content=\"Reference of 68703-67-3,Some common heterocyclic compound, 68703-67-3, name is 4-Amino-1H-pyrazole-3-carbonitrile, molecular formula is C4H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2258\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-15T18:44:44+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2258\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2258\",\"name\":\"Some tips on 68703-67-3\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-03-15T18:44:44+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Reference of 68703-67-3,Some common heterocyclic compound, 68703-67-3, name is 4-Amino-1H-pyrazole-3-carbonitrile, molecular formula is C4H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2258#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=2258\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2258#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Some tips on 68703-67-3\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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