{"id":2252,"date":"2021-03-15T02:46:48","date_gmt":"2021-03-14T18:46:48","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2252"},"modified":"2021-03-15T02:46:48","modified_gmt":"2021-03-14T18:46:48","slug":"discovery-of-6314-23-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2252","title":{"rendered":"Discovery of 6314-23-4"},"content":{"rendered":"

Application of 6314-23-4<\/a>,Some common heterocyclic compound, 6314-23-4, name is 2-(1-Pyrazolyl)ethanol, molecular formula is C5H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

General procedure: 30 g (0.2 mol) of phosphorus oxychloride was added to a mixture of 11.2 g of (0.1 mol) of 2-(1H-pyrazol-1-yl)ethanol I and 95.0 g (0.6 mol) of DMF upon stirring at 90C (maintaining the temperature below 120C). The reaction mixture was stirred during 1 hour at 100C, cooled, and neutralized with aqueous Na2CO3. The reaction product was extracted with chloroform and dried over magnesium sulfate. After removing the solvent, the residue was distilled in vacuum. Yield 9.7 g (75%), bp 47-48C (1 mmHg), nD20 1.5020, d420 1.1190 g\/mL. IR spectrum, nu, cm-1: 1520 (ring). 1HNMR data coincided with that in [6].<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(1-Pyrazolyl)ethanol, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(1-Pyrazolyl)ethanol, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[365,131],"tags":[126],"class_list":["post-2252","post","type-post","status-publish","format-standard","hentry","category-6314-23-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nDiscovery of 6314-23-4<\/title>\n<meta name=\"description\" content=\"Application of 6314-23-4,Some common heterocyclic compound, 6314-23-4, name is 2-(1-Pyrazolyl)ethanol, molecular formula is C5H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2252\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Discovery of 6314-23-4\" \/>\n<meta property=\"og:description\" content=\"Application of 6314-23-4,Some common heterocyclic compound, 6314-23-4, name is 2-(1-Pyrazolyl)ethanol, molecular formula is C5H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2252\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-14T18:46:48+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2252\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2252\",\"name\":\"Discovery of 6314-23-4\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-03-14T18:46:48+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Application of 6314-23-4,Some common heterocyclic compound, 6314-23-4, name is 2-(1-Pyrazolyl)ethanol, molecular formula is C5H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2252#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=2252\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2252#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Discovery of 6314-23-4\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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