{"id":2247,"date":"2021-03-15T02:46:48","date_gmt":"2021-03-14T18:46:48","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2247"},"modified":"2021-03-15T02:46:48","modified_gmt":"2021-03-14T18:46:48","slug":"the-important-role-of-149739-65-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2247","title":{"rendered":"The important role of 149739-65-1"},"content":{"rendered":"

Application of 149739-65-1<\/a>, The chemical industry reduces the impact on the environment during synthesis 149739-65-1, name is 3-(3-Bromophenyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.<\/p>\n

Synthesis of intermediate compound 4[00107] In a 300 ml eggplant-type flask, 7.00 g (31.4 mmol) of compound 3, 3.30 g (34.5 mmol) of sodium tert-butoxide, and 100 ml of DMF were placed. Then, 2.15 ml (34.5 mmol) of idomethane was added dropwise to the resultant mixture, followed by stirring at room temperature for 24 hours. The loss of the raw materials and production of a new compound were confirmed by TLC (Thin Layer Chromatography) . The reaction solution was concentrated, and an organic phase was recovered by three times of separation with toluene\/water. The organic phase was dried over magnesium sulfate,concentrated, and then purified by silica gel columnchromatography (developing solvent toluene : heptane : ethyl acetate = 10:10:1). A target substance was concentrated to produce 5.21 g (22.0 mmol) of compound 4 (yield 70.0%).Nine protons were attributed by 1H-NMR (CDC13: 7.95 (s, 1H) , 7.71 ppm (d, 1H) , 7.42-7.39 ppm (m, 2H) , 7.26 ppm (t, 1H) , 6.53 ppm (d, 1H) , 3.96 ppm (s, 3H) ) . A peak was observed at m\/z = 236 in GS-MS (gas chromatography direct-coupled to mass spectrometry) to confirm the target compound.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(3-Bromophenyl)-1H-pyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(3-Bromophenyl)-1H-pyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[461,131],"tags":[127],"class_list":["post-2247","post","type-post","status-publish","format-standard","hentry","category-149739-65-1","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nThe important role of 149739-65-1<\/title>\n<meta name=\"description\" content=\"Application of 149739-65-1, The chemical industry reduces the impact on the environment during synthesis 149739-65-1, name is 3-(3-Bromophenyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=2247\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 149739-65-1\" \/>\n<meta property=\"og:description\" content=\"Application of 149739-65-1, The chemical industry reduces the impact on the environment during synthesis 149739-65-1, name is 3-(3-Bromophenyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=2247\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-14T18:46:48+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=2247\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=2247\",\"name\":\"The important role of 149739-65-1\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-03-14T18:46:48+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Application of 149739-65-1, The chemical industry reduces the impact on the environment during synthesis 149739-65-1, name is 3-(3-Bromophenyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.\",\"breadcrumb\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=2247#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.pyrazoles-derivatives.com\/?p=2247\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=2247#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The important role of 149739-65-1\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The important role of 149739-65-1","description":"Application of 149739-65-1, The chemical industry reduces the impact on the environment during synthesis 149739-65-1, name is 3-(3-Bromophenyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/www.pyrazoles-derivatives.com\/?p=2247","og_locale":"en_US","og_type":"article","og_title":"The important role of 149739-65-1","og_description":"Application of 149739-65-1, The chemical industry reduces the impact on the environment during synthesis 149739-65-1, name is 3-(3-Bromophenyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.","og_url":"http:\/\/www.pyrazoles-derivatives.com\/?p=2247","og_site_name":"pyrazoles-derivatives","article_published_time":"2021-03-14T18:46:48+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"http:\/\/www.pyrazoles-derivatives.com\/?p=2247","url":"http:\/\/www.pyrazoles-derivatives.com\/?p=2247","name":"The important role of 149739-65-1","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2021-03-14T18:46:48+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Application of 149739-65-1, The chemical industry reduces the impact on the environment during synthesis 149739-65-1, name is 3-(3-Bromophenyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.","breadcrumb":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/?p=2247#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["http:\/\/www.pyrazoles-derivatives.com\/?p=2247"]}]},{"@type":"BreadcrumbList","@id":"http:\/\/www.pyrazoles-derivatives.com\/?p=2247#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"The important role of 149739-65-1"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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