{"id":2245,"date":"2021-03-15T02:46:48","date_gmt":"2021-03-14T18:46:48","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2245"},"modified":"2021-03-15T02:46:48","modified_gmt":"2021-03-14T18:46:48","slug":"share-a-compound-49633-25-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2245","title":{"rendered":"Share a compound : 49633-25-2"},"content":{"rendered":"

Electric Literature of 49633-25-2<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 49633-25-2 as follows.<\/p>\n

[00754] Intermediate 80a: benzyl 2-(3-isopropylpyrazol-1 -yI)acetate[00755] 5-lsopropyl-1H-pyrazole (1 00mg, 0.91 mmol) and potassium carbonate (376mg, 2.72mmol) was left to stir in MeCN (3mL) for 30 mins before the addition of benzyl bromoacetate (0.21 mL, 1 .36mmol). The resultant mixture was heated to 60 C and left to stir at temperature overnight. The reaction was then quenched by addition of water (2OmL) and extracted with EtOAc (3 x 20 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo to give benzyl 2-(3-isopropylpyrazol-1-yl)acetate (200mg, 0.77mmol, 85%) which was used inthe next step without further purification.1H NMR (CDCI3,400MHZ) O\/ppm: 7.41-7.33 (6H, m), 6.18 (1H, d, J= 2.3Hz), 5.21 (2H, 5), 4.96 (2H, 5), 3.04 (1H, sept, J= 7.0Hz), 1.31 (3H, 5), 1.29 (3H, 5).MS Method 2: RT: 1.87 mi mlz 259.0 [M+H]<\/p>\n

According to the analysis of related databases, 49633-25-2, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 49633-25-2, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[230,131],"tags":[126],"class_list":["post-2245","post","type-post","status-publish","format-standard","hentry","category-49633-25-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nShare a compound : 49633-25-2<\/title>\n<meta name=\"description\" content=\"Electric Literature of 49633-25-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 49633-25-2 as follows.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2245\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Share a compound : 49633-25-2\" \/>\n<meta property=\"og:description\" content=\"Electric Literature of 49633-25-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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