{"id":2237,"date":"2021-03-15T02:46:48","date_gmt":"2021-03-14T18:46:48","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2237"},"modified":"2021-03-15T02:46:48","modified_gmt":"2021-03-14T18:46:48","slug":"the-important-role-of-151521-49-2-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2237","title":{"rendered":"The important role of 151521-49-2"},"content":{"rendered":"

Synthetic Route of 151521-49-2<\/a>, These common heterocyclic compound, 151521-49-2, name is 4-Isopropyl-1H-pyrazol-5-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

To a chilled solution of 4-isopropyl-1 H-pyrazol-5-amine (2.5 g, 20 mmol) in 20 ml DCM ethoxycarbonyl isothiocyanate (2.6 g, 20 mmol) dissolved in 10 ml DCM were added dropwise. The resulting suspension was further diluted with 30 ml DCM and stirred for 2 h. The product was collected, washed with DCM and dried. 2.0 g (7.8 mmol) of thisraw material together with 3.2 g (23.4 mmol) were then refluxed in 15 ml MeCN for 2 h. After careful neutralization with acetic acid the solvent was removed in vacuo. The remaining solid was suspended in water. The product was collected, washed with water and dried to yield title compound (II) as colorless powder. 1 H-NMR (400MHz, d6-DMSO, 300K) delta 1 .14 (d, J = 6.8 Hz, 6H), 3.12 (h, J = 6.8 Hz, 1 H), 7.88 (s, 1 H), 12.60 (s, broad, 1 H), 13.34 (s, broad, 1 H); MS (ES) C8H10N4OS, requires 210.06, found 21 1 .3 (M+H)+.<\/p>\n

Statistics shows that 4-Isopropyl-1H-pyrazol-5-amine is playing an increasingly important role. we look forward to future research findings about 151521-49-2.<\/p>\n","protected":false},"excerpt":{"rendered":"

Statistics shows that 4-Isopropyl-1H-pyrazol-5-amine is playing an increasingly important role. we look forward to future research findings about 151521-49-2.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[422,131],"tags":[126],"class_list":["post-2237","post","type-post","status-publish","format-standard","hentry","category-151521-49-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 151521-49-2<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 151521-49-2, These common heterocyclic compound, 151521-49-2, name is 4-Isopropyl-1H-pyrazol-5-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2237\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 151521-49-2\" \/>\n<meta property=\"og:description\" content=\"Synthetic Route of 151521-49-2, These common heterocyclic compound, 151521-49-2, name is 4-Isopropyl-1H-pyrazol-5-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2237\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-14T18:46:48+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2237\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2237\",\"name\":\"The important role of 151521-49-2\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-03-14T18:46:48+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Synthetic Route of 151521-49-2, These common heterocyclic compound, 151521-49-2, name is 4-Isopropyl-1H-pyrazol-5-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2237#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=2237\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2237#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The important role of 151521-49-2\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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