{"id":2230,"date":"2021-03-15T02:45:49","date_gmt":"2021-03-14T18:45:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2230"},"modified":"2021-03-15T02:45:49","modified_gmt":"2021-03-14T18:45:49","slug":"the-important-role-of-105434-90-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2230","title":{"rendered":"The important role of 105434-90-0"},"content":{"rendered":"

Electric Literature of 105434-90-0<\/a>, The chemical industry reduces the impact on the environment during synthesis 105434-90-0, name is Ethyl 5-amino-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life.<\/p>\n

LAH (20 mg, 0.51 mmol) was added to an ice cooled solution of ethyl 5-amino-l-((2-(5-phenylisoxazole-3-carboxamido)ethyl)sulfonyl)-lH- pyrazole-3-carboxylate (100 mg, 0.2537 mmol) in THF (10 mL) and the reaction mixture was stirred for 1 h at the same temperature. Then the reaction mixture was quenched with saturated NH4C1 solution and filtered through celite pad. The filtrate was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford crude compound which was further purified by preparative HPLC to obtain N-(2-((5-amino-3-(hydroxymethyl)-lH-pyrazol-l- yl)sulfonyl)ethyl)-5-phenylisoxazole-3-carboxamide (23 mg, 7% over two steps). (0261) [00169] Appearance: white solid (0262) [00170] Analytical data: XH NMR (400 MHz, DMSO-d6): delta 8.89-8.87 (m, IH), 7.94-7.92 (m, 2H), 7.58-7.54 (m, 3H), 7.36 (s, IH), 6.07 (s, D20 exchangeable, 2H), 5.34 (s, IH), 5.16 (t, J=6.0 Hz, IH), 4.25 (d, J=6.0 Hz, 2H), 3.76 (t, J=6.6 Hz, 2H), 3.61-3.56 (m, 2H). (0263) [00171] LC-MS: [M+H]+=391.9 (0264) [00172] HPLC Purity: 98.50% at 254 nm and 98.37% at 220 nm.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 5-amino-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 5-amino-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[411,131],"tags":[126],"class_list":["post-2230","post","type-post","status-publish","format-standard","hentry","category-105434-90-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 105434-90-0<\/title>\n<meta name=\"description\" content=\"Electric Literature of 105434-90-0, The chemical industry reduces the impact on the environment during synthesis 105434-90-0, name is Ethyl 5-amino-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2230\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 105434-90-0\" \/>\n<meta property=\"og:description\" content=\"Electric Literature of 105434-90-0, The chemical industry reduces the impact on the environment during synthesis 105434-90-0, name is Ethyl 5-amino-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2230\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-14T18:45:49+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2230\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2230\",\"name\":\"The important role of 105434-90-0\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-03-14T18:45:49+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Electric Literature of 105434-90-0, The chemical industry reduces the impact on the environment during synthesis 105434-90-0, name is Ethyl 5-amino-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2230#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=2230\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2230#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The important role of 105434-90-0\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The important role of 105434-90-0","description":"Electric Literature of 105434-90-0, The chemical industry reduces the impact on the environment during synthesis 105434-90-0, name is Ethyl 5-amino-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=2230","og_locale":"en_US","og_type":"article","og_title":"The important role of 105434-90-0","og_description":"Electric Literature of 105434-90-0, The chemical industry reduces the impact on the environment during synthesis 105434-90-0, name is Ethyl 5-amino-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=2230","og_site_name":"pyrazoles-derivatives","article_published_time":"2021-03-14T18:45:49+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=2230","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=2230","name":"The important role of 105434-90-0","isPartOf":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2021-03-14T18:45:49+00:00","author":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Electric Literature of 105434-90-0, The chemical industry reduces the impact on the environment during synthesis 105434-90-0, name is Ethyl 5-amino-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life.","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=2230#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=2230"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=2230#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"http:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"The important role of 105434-90-0"}]},{"@type":"WebSite","@id":"http:\/\/www.pyrazoles-derivatives.com\/#website","url":"http:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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