{"id":2220,"date":"2021-03-15T02:45:49","date_gmt":"2021-03-14T18:45:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2220"},"modified":"2021-03-15T02:45:49","modified_gmt":"2021-03-14T18:45:49","slug":"extracurricular-laboratory-synthetic-route-of-632365-54-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2220","title":{"rendered":"Extracurricular laboratory: Synthetic route of 632365-54-9"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 632365-54-9, name is Methyl 5-amino-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., name: Methyl 5-amino-1H-pyrazole-3-carboxylate<\/a><\/p>\n

[00126] delta-Amino-S-pyrazolcarboxylic acid methyl ester (16.91 g, 119.8 mmol) is dissolved in ethanol (2.4 L) and hydrochloric acid (37%, 12.5 ml_, 150 mmol) is added. Then, a solution of 2-bromo-malonaldehyde (18.9 g, 125.2 mmol) in ethanol (1.4 L) and is quickly added in a dropwise manner at RT. After 30 min, a precipitation is observed; after 6 hours the precipitate is filtered and washed with 50 mL ethanol and thereafter with 50 mL diethyl ether to give 4.19 g of 6-bromo-pyrazolo[1 ,5a]pyrimidine-2-carboxylic acid methyl ester. After evaporation of the filtrate and crystallisation, an additional 1.43 g of product is obtained. Totally 5.62 g (18.3 %).<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[303,131],"tags":[126],"class_list":["post-2220","post","type-post","status-publish","format-standard","hentry","category-632365-54-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtracurricular laboratory: Synthetic route of 632365-54-9<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 632365-54-9, name is Methyl 5-amino-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., name: Methyl 5-amino-1H-pyrazole-3-carboxylate\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2220\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Extracurricular laboratory: Synthetic route of 632365-54-9\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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