{"id":2218,"date":"2021-03-15T02:45:49","date_gmt":"2021-03-14T18:45:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2218"},"modified":"2021-03-15T02:45:49","modified_gmt":"2021-03-14T18:45:49","slug":"extended-knowledge-of-127107-23-7-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2218","title":{"rendered":"Extended knowledge of 127107-23-7"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127107-23-7, Application In Synthesis of 1-Methyl-1H-pyrazol-4-amine hydrochloride<\/a><\/p>\n

Synthesis of Compound 1-8. Into a 25-mL round-bottom flask, was placed 8.5 (50 mg, 0.15 mmol, 1.00 equiv), l-methyl-lH-pyrazol-4-amine hydrochloride (30 mg, 0.22 mmol, 1.50 equiv), K3P04 (99 mg, 0.45 mmol, 3.00 equiv), Xphos-Pd (13 mg, 0.10 equiv) in tert-butanol (5 mL). The resulting solution was stirred for 4 h at 80 C. The resulting mixture was concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with dichloromethane\/methanol (20: 1). This resulted in 34 mg (58%) of 1-8 as a yellow solid. LC-MS (ESI, m\/z): 398 (M+H+); MR (300 MHz, CD3OD) delta 8.62 (s, 1H), 7.94 (s, 1H), 7.86 (s, 1H), 7.65 (s, 1H), 4.24 (m, 1H), 3.98 (m, 4H), 3.89 (s, 3H), 3.42 (s, 4H), 2.34 (m, 4H), 1.53-1.76 (m, 4H).<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298,131],"tags":[126],"class_list":["post-2218","post","type-post","status-publish","format-standard","hentry","category-127107-23-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtended knowledge of 127107-23-7<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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