{"id":2208,"date":"2021-03-12T04:49:48","date_gmt":"2021-03-11T20:49:48","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2208"},"modified":"2021-03-12T04:49:48","modified_gmt":"2021-03-11T20:49:48","slug":"introduction-of-a-new-synthetic-route-about-31230-17-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2208","title":{"rendered":"Introduction of a new synthetic route about 31230-17-8"},"content":{"rendered":"

Related Products of 31230-17-8<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 31230-17-8 as follows.<\/p>\n

Example 118a 5-Bromo-1-methyl-3-(5-methyl-1H-pyrazol-3-ylamino)pyridin-2(1H)-one 118a A 100-mL single-neck round-bottomed flask equipped with a magnetic stirrer and reflux condenser was charged with 1,4-dioxane (15 mL), 5-methyl-1H-pyrazol-3-amine (1 g, 10 mmol) (1), 3,5-dibromo-1-methylpyridin-2(1H)-one (4 g, 15 mmol) (2), and cesium carbonate (6.4 g, 20 mmol). Xantphos (400 mg, 0.8 mmol) and Pd2(dba)3 (700 mg, 0.8 mmol) were added, and the reaction mixture was heated at 100\u00a1\u00e3 C. for 5 h. After this time the reaction was cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure and the residue was purified on flush column eluting with dichloromethane:methanol (20:1) to afford 118a (1.0 g, 35percent). MS: [M+H]+ 283.<\/p>\n

According to the analysis of related databases, 31230-17-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 31230-17-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[207,131],"tags":[145],"class_list":["post-2208","post","type-post","status-publish","format-standard","hentry","category-31230-17-8","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nIntroduction of a new synthetic route about 31230-17-8<\/title>\n<meta name=\"description\" content=\"Related Products of 31230-17-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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