{"id":2206,"date":"2021-03-12T04:49:48","date_gmt":"2021-03-11T20:49:48","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2206"},"modified":"2021-03-12T04:49:48","modified_gmt":"2021-03-11T20:49:48","slug":"share-a-compound-942853-22-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2206","title":{"rendered":"Share a compound : 942853-22-7"},"content":{"rendered":"

Related Products of 942853-22-7<\/a>,Some common heterocyclic compound, 942853-22-7, name is 1-(2,2,2-Trifluoroethyl)-1H-pyrazole-3-carboxylic acid, molecular formula is C6H5F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

Intermediate Ck is prepared from Ak by treatment with 4 N HCI\/dioxane for 1 h followed by concentration in vacuo. Acid R2i (12.2 mg, 0.063 mmol) is dissolved in DMF (1 ml_), then TEA (29 muIota_, 0.210 mmol) is added followed by TBTU (19.4 mg, 0.060 mmol). The solution is stirred for 15 mins, after which the amine hydrochloride Ck (40 mg, 0.053 mmol) is added in DMF (1 mL). The solution is stirred at RT for 16 h. AcOH is added and the resulting solution is filtered through a Millex filter and purified by prep HPLC (Sunfire column, 0.1% TFA). The pure fractions are combined, frozen and lyophilized to provide compound 1023.FIA M.S.(electrospray) : 900.4 (M+H)+ Retention time (min) = 6.4 min1H NMR (400 MHz,DMSO-d6): delta 10.82 (s, 1H) , 8.94 (s, 1H), 7.96 (d, 1H, J = 7.1 Hz), 7.93 (d, 1H, J = 2.3 Hz), 7.84 (d, 1H, J = 9 Hz), 7.07 (d, 1H, J = 9.4 Hz), 6.74 (d, 1 H, J = 2.3 Hz), 6.40 (s, 1 H), 5.65-5.58 (m 1 H), 5.48-5.43 (m, 1 H), 5.32 (qn, 1 H J = 7.8 Hz), 5.22 (q, 2H, J = 9 Hz), 5.06 (dd, 1H, J = 9.8, 9.4 Hz), 4.63-4.57 (m, 1H), 4.54 (d, 1H, J= 11.8), 4.41 (dd, 1H, J= 7.4, 7.0 Hz), 4.04-4.00 (m, 1H), 3.87 (s, 3H), 2.64-2.58 (m, 2H), 2.43 (s, 3H), 2.38-2.31 (m, 3H), 2.15-2.08 (m, 2H), 2.01-1.98 (m, 1H), 1.85-1.67 (m, 3H), 1.59-1.23 (m, 15H), 0.90-0.86 (m, 2H).<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(2,2,2-Trifluoroethyl)-1H-pyrazole-3-carboxylic acid, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(2,2,2-Trifluoroethyl)-1H-pyrazole-3-carboxylic acid, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[458,131],"tags":[126],"class_list":["post-2206","post","type-post","status-publish","format-standard","hentry","category-942853-22-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nShare a compound : 942853-22-7<\/title>\n<meta name=\"description\" content=\"Related Products of 942853-22-7,Some common heterocyclic compound, 942853-22-7, name is 1-(2,2,2-Trifluoroethyl)-1H-pyrazole-3-carboxylic acid, molecular formula is C6H5F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2206\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Share a compound : 942853-22-7\" \/>\n<meta property=\"og:description\" content=\"Related Products of 942853-22-7,Some common heterocyclic compound, 942853-22-7, name is 1-(2,2,2-Trifluoroethyl)-1H-pyrazole-3-carboxylic acid, molecular formula is C6H5F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2206\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-11T20:49:48+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2206\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2206\",\"name\":\"Share a compound : 942853-22-7\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-03-11T20:49:48+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Related Products of 942853-22-7,Some common heterocyclic compound, 942853-22-7, name is 1-(2,2,2-Trifluoroethyl)-1H-pyrazole-3-carboxylic acid, molecular formula is C6H5F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2206#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=2206\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2206#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Share a compound : 942853-22-7\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Share a compound : 942853-22-7","description":"Related Products of 942853-22-7,Some common heterocyclic compound, 942853-22-7, name is 1-(2,2,2-Trifluoroethyl)-1H-pyrazole-3-carboxylic acid, molecular formula is C6H5F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=2206","og_locale":"en_US","og_type":"article","og_title":"Share a compound : 942853-22-7","og_description":"Related Products of 942853-22-7,Some common heterocyclic compound, 942853-22-7, name is 1-(2,2,2-Trifluoroethyl)-1H-pyrazole-3-carboxylic acid, molecular formula is C6H5F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=2206","og_site_name":"pyrazoles-derivatives","article_published_time":"2021-03-11T20:49:48+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=2206","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=2206","name":"Share a compound : 942853-22-7","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2021-03-11T20:49:48+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Related Products of 942853-22-7,Some common heterocyclic compound, 942853-22-7, name is 1-(2,2,2-Trifluoroethyl)-1H-pyrazole-3-carboxylic acid, molecular formula is C6H5F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=2206#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=2206"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=2206#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Share a compound : 942853-22-7"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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