{"id":2203,"date":"2021-03-12T04:49:48","date_gmt":"2021-03-11T20:49:48","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2203"},"modified":"2021-03-12T04:49:48","modified_gmt":"2021-03-11T20:49:48","slug":"application-of-112758-40-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2203","title":{"rendered":"Application of 112758-40-4"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 112758-40-4, name is 3-Methyl-1H-pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112758-40-4, Application In Synthesis of 3-Methyl-1H-pyrazole-4-carbaldehyde<\/a><\/p>\n

To a solution of 3-methyl-iH-pyrazole-4-carbaldehyde, intermediate 12 (0.33 g, 3.0 mmol) in 10 mL of THF was added 0.12 g of 60 % sodium hydride with ice bath cooling and then it was stirred for 20 minute at the same temperature. To this, was added of 10 mL solution of l-methyl-N-(4-(methansulfonyl)pyrimidin-2-yl)-iH- indazol-5-amine (0.6g, 2.0 mmol) in THF. The reaction was allowed to warm up to room temperature and then stirred for 2 hours at rt. The reaction was quenched with water, extracted with dichloromethane (x2) and washed with brine. The collected organic layers were dried over anhydrous sodium sulfate and then concentrated in vacuo. The resulting residue was solidified with heptane and then collected by filtration to afford the desired intermediate 13 as a white solid (0.45 g, 66 %<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[168,131],"tags":[126],"class_list":["post-2203","post","type-post","status-publish","format-standard","hentry","category-112758-40-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nApplication of 112758-40-4<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 112758-40-4, name is 3-Methyl-1H-pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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