{"id":2183,"date":"2021-03-12T04:48:39","date_gmt":"2021-03-11T20:48:39","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2183"},"modified":"2021-03-12T04:48:39","modified_gmt":"2021-03-11T20:48:39","slug":"the-important-role-of-97421-13-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2183","title":{"rendered":"The important role of 97421-13-1"},"content":{"rendered":"

97421-13-1, name is 1-(tert-Butyl)-1H-pyrazol-4-amine, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 1-(tert-Butyl)-1H-pyrazol-4-amine<\/a><\/p>\n

General procedure: A solution of 4-aminopyrazole 1b-d (1.03 mol) in THF (1400 ml) was cooled to 0, then DMAP (5.03 g, 0.041 mol) was added to the stirred solution, followed by slow addition of di(tert-butyl) dicarbonate (229 g, 1.05 mol)over 30 min. The mixture was maintained at the indicated temperature for 1 h, allowed to warm to the room temperature, and stirred for further 4-6 h. The reaction mixture was then heated at 40 for 1 h, evaporated, extracted with MTBE (800 ml). The obtained oily product was diluted with 3:2 MTBE-hexane mixture (300 ml), stirred, the precipitate that formed was filtered off and air dried. tert-Butyl (1-tert-butyl-1-pyrazol-4-yl)carbamate (2b).Yield 230 g (93%), violet powder, mp 72-73C. IR spectrum,nu, cm-1: 3273 (N-H), 1710 (C=O). 1H NMR spectrum,delta, ppm (J, Hz): 1.50 (9H, s, (CH3)3); 1.56 (9H, s, (CH3)3);6.25 (1H, s, NH); 7.33 (1H, s, H-5); 7.80 (1H, s, H-3).13C NMR spectrum, delta, ppm: 27.9; 29.2; 58.0; 79.7; 116.6;120.4; 128.9; 152.8. Mass spectrum, m\/z (Irel, %): 240[+]+ (100). Found, %: C 60.02; H 8.71; N 17.44.C12H21N3O2. Calculated, %: C 60.23; H 8.84; N 17.56.<\/p>\n

The synthetic route of 97421-13-1 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 97421-13-1 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[456,131],"tags":[126],"class_list":["post-2183","post","type-post","status-publish","format-standard","hentry","category-97421-13-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 97421-13-1<\/title>\n<meta name=\"description\" content=\"97421-13-1, name is 1-(tert-Butyl)-1H-pyrazol-4-amine, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 1-(tert-Butyl)-1H-pyrazol-4-amine\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=2183\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 97421-13-1\" \/>\n<meta property=\"og:description\" content=\"97421-13-1, name is 1-(tert-Butyl)-1H-pyrazol-4-amine, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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