{"id":2162,"date":"2021-03-11T02:18:39","date_gmt":"2021-03-10T18:18:39","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2162"},"modified":"2021-03-11T02:18:39","modified_gmt":"2021-03-10T18:18:39","slug":"the-important-role-of-13808-64-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2162","title":{"rendered":"The important role of 13808-64-5"},"content":{"rendered":"

Synthetic Route of 13808-64-5<\/a>, The chemical industry reduces the impact on the environment during synthesis 13808-64-5, name is 4-Bromo-3-methylpyrazole, I believe this compound will play a more active role in future production and life.<\/p>\n

(1) Combine 16.1 g (0.1 mol) of 4-bromo-3-methyl-1H-pyrazole, 10.1 g (0.12 mol) of 3,4-dihydro-2H-pyran, and 0.7 g (0.006 mol) of trifluoroacetic acid ) Add to the reaction bottle and stir to heat to micro-reflux for 12 hours. The reaction formula is as follows:Cool to room temperature, add 0.24 g (0.006 mol) of sodium hydride to neutralize the reaction system,Vacuum distillation to obtain intermediate4-bromo-3-methyl-1- (tetrahydro-2H-pyran-2-yl) -1H-pyrazole and4-bromo-5-methyl-1- (tetrahydro-2H-pyran-2-yl) -1H-pyrazole total 24 grams,The presence of isomers does not affect the next reaction. (2) The intermediates obtained in step (1) 4-bromo-3-methyl-1- (tetrahydro-2H-pyran-2-yl) -1H-pyrazole and 4-bromo-5- Methyl-1- (tetrahydro-2H-pyran-2-yl) -1H-pyrazole 24 g was dissolved in 200 ml of THF, cooled to minus 75 degrees, and n-butyl with a concentration of 2.5 mol \/ L was added dropwise 48 ml (0.12 mol) of lithium solution, maintaining the temperature at minus 75 degrees Celsius, dropping and holding for half an hour, then adding 14 g (0.12 mol) of N-formylmorpholine at this temperature, the reaction formula in step (2) is as follows :After the reaction is completed, naturally warm to room temperature, add dilute sulfuric acid to quench until the system pH value is less than 1, stir at room temperature for 3-4 hours, neutralize with sodium bicarbonate, extract with ethyl acetate, dry and concentrate to obtain the target product by adsorption and purification on silica gel 3-Methyl-1H-pyrazole-4-carbaldehyde 8 g.The yield of the target product 3-methyl-1H-pyrazole-4-carbaldehyde in this example was 72.7%. 2 is the nuclear magnetic resonance spectrum of the product 3-methyl-1H-pyrazole-4-carbaldehyde obtained in this example;<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-methylpyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-methylpyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[240,131],"tags":[126],"class_list":["post-2162","post","type-post","status-publish","format-standard","hentry","category-13808-64-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 13808-64-5<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 13808-64-5, The chemical industry reduces the impact on the environment during synthesis 13808-64-5, name is 4-Bromo-3-methylpyrazole, I believe this compound will play a more active role in future production and life.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2162\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 13808-64-5\" \/>\n<meta property=\"og:description\" content=\"Synthetic Route of 13808-64-5, The chemical industry reduces the impact on the environment during synthesis 13808-64-5, name is 4-Bromo-3-methylpyrazole, I believe this compound will play a more active role in future production and life.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2162\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-10T18:18:39+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2162\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2162\",\"name\":\"The important role of 13808-64-5\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-03-10T18:18:39+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Synthetic Route of 13808-64-5, The chemical industry reduces the impact on the environment during synthesis 13808-64-5, name is 4-Bromo-3-methylpyrazole, I believe this compound will play a more active role in future production and life.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2162#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=2162\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2162#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The important role of 13808-64-5\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The important role of 13808-64-5","description":"Synthetic Route of 13808-64-5, The chemical industry reduces the impact on the environment during synthesis 13808-64-5, name is 4-Bromo-3-methylpyrazole, I believe this compound will play a more active role in future production and life.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=2162","og_locale":"en_US","og_type":"article","og_title":"The important role of 13808-64-5","og_description":"Synthetic Route of 13808-64-5, The chemical industry reduces the impact on the environment during synthesis 13808-64-5, name is 4-Bromo-3-methylpyrazole, I believe this compound will play a more active role in future production and life.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=2162","og_site_name":"pyrazoles-derivatives","article_published_time":"2021-03-10T18:18:39+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=2162","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=2162","name":"The important role of 13808-64-5","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2021-03-10T18:18:39+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Synthetic Route of 13808-64-5, The chemical industry reduces the impact on the environment during synthesis 13808-64-5, name is 4-Bromo-3-methylpyrazole, I believe this compound will play a more active role in future production and life.","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=2162#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=2162"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=2162#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"The important role of 13808-64-5"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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