{"id":2160,"date":"2021-03-11T02:17:40","date_gmt":"2021-03-10T18:17:40","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2160"},"modified":"2021-03-11T02:17:40","modified_gmt":"2021-03-10T18:17:40","slug":"application-of-3528-45-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2160","title":{"rendered":"Application of 3528-45-8"},"content":{"rendered":"

Related Products of 3528-45-8<\/a>, A common heterocyclic compound, 3528-45-8, name is 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine, molecular formula is C11H13N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

To a solution of 3-[l-(2,3-dimethyl-phenyl)-lH-tetrazol-5-yl]-propionic acid (49 mg, 0.20 mmol, 1.0 eq.) and 2-(4-methoxy-benzyl)-2H-pyrazol-3-ylamine (40 mg, 0.20 mmol, 1.0 eq.) in DMF (1.2 mL), lambda\/-(3-dimethylaminopropyl)-lambdaf-ethylcarbodiimide hydrochloride (57 mg, 0.30 mmol, 1.5 eq.) and 4-dimethylaminopyridine (36 mg, 0.30 mmol, 1.5 eq.) were added in sequence. The mixture was stirred at r.t. for 18 hours. The mixture was purified by prep. etaPLC and evaporated to afford the title compound. LC-MS (B): tR = 0.85 min; [M+eta]+ = 432.12.<\/p>\n

The synthetic route of 3528-45-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 3528-45-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[312,131],"tags":[127],"class_list":["post-2160","post","type-post","status-publish","format-standard","hentry","category-3528-45-8","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nApplication of 3528-45-8<\/title>\n<meta name=\"description\" content=\"Related Products of 3528-45-8, A common heterocyclic compound, 3528-45-8, name is 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine, molecular formula is C11H13N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2160\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Application of 3528-45-8\" \/>\n<meta property=\"og:description\" content=\"Related Products of 3528-45-8, A common heterocyclic compound, 3528-45-8, name is 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine, molecular formula is C11H13N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2160\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-10T18:17:40+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2160\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2160\",\"name\":\"Application of 3528-45-8\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-03-10T18:17:40+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Related Products of 3528-45-8, A common heterocyclic compound, 3528-45-8, name is 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine, molecular formula is C11H13N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2160#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=2160\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2160#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Application of 3528-45-8\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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