{"id":2147,"date":"2021-03-11T02:17:40","date_gmt":"2021-03-10T18:17:40","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2147"},"modified":"2021-03-11T02:17:40","modified_gmt":"2021-03-10T18:17:40","slug":"extended-knowledge-of-175137-46-9-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2147","title":{"rendered":"Extended knowledge of 175137-46-9"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 175137-46-9, category: pyrazoles-derivatives<\/a><\/p>\n

A mixture of (S)-6-chloro-Lambda\/-(l-(4-fluorophenyl)ethyl)-3-nitropyridin-2-aniine (Method 19; 1.74 g, 5.88 mmol), S-cyclopropyl-lH-pyrazol-S-amine (0.91 g, 7.36 mmol), and DIEA (1.28 ml, 7.36 mmol) in W-BuOH (10 ml) was heated in a sealed tube at 160 C for 60 hours. The solvent was removed under reduced pressure and the residue was purified by chromatography (hexane: EtOAc = 1 : 1) to give the title compound as a yellow solid (1.35 g, 60%). NMR (400 MHz) 12.15 (s, IH), 10.43 (br, IH), 9.19 (br, IH), 8.12 (d, J= 9.2 Hz, IH), 7.45 (m, 2H), 7.17 (m, 2H), 6.25 (br, IH), 6.14 (br, IH), 5.45 (m, IH), 1.87 (m, IH), 1.60 (d, J= 6.8 Hz, 3H), 0.95 (m, 2H)5 0.65 (m, 2H). MS: Calcd.: 382; Found: [M+H]+ 383.<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[189,131],"tags":[126],"class_list":["post-2147","post","type-post","status-publish","format-standard","hentry","category-175137-46-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtended knowledge of 175137-46-9<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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