{"id":2138,"date":"2021-03-10T02:50:54","date_gmt":"2021-03-09T18:50:54","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2138"},"modified":"2021-03-10T02:50:54","modified_gmt":"2021-03-09T18:50:54","slug":"continuously-updated-synthesis-method-about-75090-52-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2138","title":{"rendered":"Continuously updated synthesis method about 75090-52-7"},"content":{"rendered":"

These common heterocyclic compound, 75090-52-7, name is 7-Bromo-4-chloroquinoline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H5BrClN<\/a><\/p>\n

17 A solution of 4-chloro-7-bromoquinoline 17-A (1 g, 4.1 mmol) (see Scheme 1 : general preparation of quinolines), hexamethyidistannane 17-B (1.35 g, 4.1 mmol) and [(C6H5)P]4Pd (237 mg) in 1,4-dioxane (10 ml) was heated to 105-110 C for 2 hours. The solution was cooled to room temperature. Column chromatography (hexane\/EtOAc 5: 1) gave 4-chloro-7- (trimethylstannyl) quinoline 17-C (1.26 g, 94%).<\/p>\n

The synthetic route of 7-Bromo-4-chloroquinoline has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 7-Bromo-4-chloroquinoline has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[450,427],"tags":[127],"class_list":["post-2138","post","type-post","status-publish","format-standard","hentry","category-75090-52-7","category-quinolines-derivatives","tag-m-w200-300"],"yoast_head":"\nContinuously updated synthesis method about 75090-52-7<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 75090-52-7, name is 7-Bromo-4-chloroquinoline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H5BrClN\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2138\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Continuously updated synthesis method about 75090-52-7\" \/>\n<meta property=\"og:description\" content=\"These common heterocyclic compound, 75090-52-7, name is 7-Bromo-4-chloroquinoline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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