{"id":2134,"date":"2021-03-10T02:50:54","date_gmt":"2021-03-09T18:50:54","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2134"},"modified":"2021-03-10T02:50:54","modified_gmt":"2021-03-09T18:50:54","slug":"continuously-updated-synthesis-method-about-68236-20-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2134","title":{"rendered":"Continuously updated synthesis method about 68236-20-4"},"content":{"rendered":"

Related Products of 68236-20-4<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68236-20-4 name is 2-Chloro-7-methoxyquinoline-3-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

General procedure: Anhydrous DMF (1 mL) and Et3N (0.56 mL, 4.00 mmol, 4equiv), previously degassed with bubbling argon for 10 min, were added to a flask containing the appropriate chlorinated quinoline(1.00 mmol, 1 equiv), [PdCl2(PPh3)2] (35.1 mg, 0.050 mmol, 0.05equiv), and CuI (9.5 mg, 0.050 mmol, 0.05 equiv) under an argon atmosphere.Finally, the appropriate alkyne derivative (1.20 mmol, 1.2equiv) was added dropwise to the mixture, which was then stirred over night at r.t. After completion of the reaction (attested by TLCanalysis), the mixture was filtered through a short pad of silica and Celite and eluted with EtOAc. The crude was concentrated under reduced pressure and purified by column chromatography (silica gel, various solvent mixtures).<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-7-methoxyquinoline-3-carbaldehyde, and friends who are interested can also refer to it.<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-7-methoxyquinoline-3-carbaldehyde, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[448,427],"tags":[127],"class_list":["post-2134","post","type-post","status-publish","format-standard","hentry","category-68236-20-4","category-quinolines-derivatives","tag-m-w200-300"],"yoast_head":"\nContinuously updated synthesis method about 68236-20-4<\/title>\n<meta name=\"description\" content=\"Related Products of 68236-20-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68236-20-4 name is 2-Chloro-7-methoxyquinoline-3-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=2134\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Continuously updated synthesis method about 68236-20-4\" \/>\n<meta property=\"og:description\" content=\"Related Products of 68236-20-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68236-20-4 name is 2-Chloro-7-methoxyquinoline-3-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Continuously updated synthesis method about 68236-20-4","description":"Related Products of 68236-20-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68236-20-4 name is 2-Chloro-7-methoxyquinoline-3-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/www.pyrazoles-derivatives.com\/?p=2134","og_locale":"en_US","og_type":"article","og_title":"Continuously updated synthesis method about 68236-20-4","og_description":"Related Products of 68236-20-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68236-20-4 name is 2-Chloro-7-methoxyquinoline-3-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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