{"id":2133,"date":"2021-03-10T02:50:54","date_gmt":"2021-03-09T18:50:54","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2133"},"modified":"2021-03-10T02:50:54","modified_gmt":"2021-03-09T18:50:54","slug":"application-of-75457-13-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2133","title":{"rendered":"Application of 75457-13-5"},"content":{"rendered":"<p>75457-13-5, name is 3-Methylquinolin-8-ol, belongs to quinolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. <a href=\"https:\/\/www.ambeed.com\/products\/75457-13-5.html\">COA of Formula: C10H9NO<\/a><\/p>\n<p>A) A solution of 3-methyl-8-hydroxyquinoline (15.9 g, 0.10 mole) is added to a mixture of 70% nitric acid (162 g, 1.8 mole) (18 molar equivalents) and Manganese dioxide (0.33 g, 0.0038 mole) (0.038 molar equivalents) at a temperature of 80-100 C. over a 1 hour period, with stirring. The resultant overhead gases are scrubbed and vented. The reaction mixture is heated at 100-105 C. for 4 hours, cooled to 85 C., treated with 88% formic acid at 85-95 C. over a 20 minute period, further heated at 85-95 C. for 0.5 hour, cooled to 0 C., stirred for 0.5 hour and filtered. The filtercake is washed with acetone to give 5-methyl-2,3-pyridinedicarboxylic acid, 13.6 g (78.3% yield), 98.8% purity by HPLC analysis.<\/p>\n<p>The synthetic route of 75457-13-5 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The synthetic route of 75457-13-5 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[447,427],"tags":[126],"class_list":["post-2133","post","type-post","status-publish","format-standard","hentry","category-75457-13-5","category-quinolines-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Application of 75457-13-5<\/title>\n<meta name=\"description\" content=\"75457-13-5, name is 3-Methylquinolin-8-ol, belongs to quinolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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