{"id":2131,"date":"2021-03-10T02:50:54","date_gmt":"2021-03-09T18:50:54","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2131"},"modified":"2021-03-10T02:50:54","modified_gmt":"2021-03-09T18:50:54","slug":"continuously-updated-synthesis-method-about-139399-67-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2131","title":{"rendered":"Continuously updated synthesis method about 139399-67-0"},"content":{"rendered":"

Application of 139399-67-0<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 139399-67-0 name is 3-Bromoquinolin-8-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

8-Amino-3-bromoquinoline (4) (0.3 g, 1.3 mmol) was dissolved in 10 mL of 70% sulfuric acid and placed in a Q-Tube (Sigma Aldrich). The tube was sealed and heated with stirring at 22000 for 3 days. After cooling to ambient temperature, the reaction solution was brought to pH 8 by addition of NH4OH (16 M), followed by extraction with ethyl acetate (4 x 25 mL). The organic phases were combined, dried over Na2504, filtered, and evaporated todryness. The crude product was purified by column chromatography on silica gel (7 g) using3:1 dichloromethane\/hexane as the eluent. Fractions containing the product were combinedand evaporated to dryness to give 5 as a white solid 0.184 g (34% yield, mp 99-101 00, litmp 111.5-1 12.5 00) 1H NMR (400 MHz, ODd3) O 8.77 (1H, d, J= 2.0 Hz), 8.32 (1H, d, J=2.0 Hz), 7.99 (1H, 5), 7.48 (1H, t, J= 8.0 Hz), 7.18 (1H, dd, J= 23.2 Hz, J= 9.6 Hz). LCMSfound 225.90, [M+2H].<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromoquinolin-8-amine, and friends who are interested can also refer to it.<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromoquinolin-8-amine, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[445,427],"tags":[127],"class_list":["post-2131","post","type-post","status-publish","format-standard","hentry","category-139399-67-0","category-quinolines-derivatives","tag-m-w200-300"],"yoast_head":"\nContinuously updated synthesis method about 139399-67-0<\/title>\n<meta name=\"description\" content=\"Application of 139399-67-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 139399-67-0 name is 3-Bromoquinolin-8-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=2131\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Continuously updated synthesis method about 139399-67-0\" \/>\n<meta property=\"og:description\" content=\"Application of 139399-67-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 139399-67-0 name is 3-Bromoquinolin-8-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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The downstream synthesis method of this compound is introduced below.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/www.pyrazoles-derivatives.com\/?p=2131","og_locale":"en_US","og_type":"article","og_title":"Continuously updated synthesis method about 139399-67-0","og_description":"Application of 139399-67-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 139399-67-0 name is 3-Bromoquinolin-8-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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