{"id":2125,"date":"2021-03-10T02:49:46","date_gmt":"2021-03-09T18:49:46","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2125"},"modified":"2021-03-10T02:49:46","modified_gmt":"2021-03-09T18:49:46","slug":"new-downstream-synthetic-route-of-391-77-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2125","title":{"rendered":"New downstream synthetic route of 391-77-5"},"content":{"rendered":"

Related Products of 391-77-5<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 391-77-5 name is 4-Chloro-6-fluoroquinoline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

To a homogeneous mixture of 4-chloro-6-fluoroquinoline (500.0 mg, 2.8 mmol)inNMP (5 mL), in a sealable vial, was added 1-Boc-piperazine (750.0 mg, 4.0 mmol) followed by DIPEA (2 mL, 11.6 mmol). After the addition was complete, the vial was capped and the mixture was stirred at 120 C. After 15 hours, the reaction was cooled to room temperature then partitioned between water and Et20. The layers were separated and the aqueous layer was extracted twice more with Et20 then once with EtOAc. Theseorganic extracts were combined with the original organic layer and were washed with brine, dried (Na2SO4), filtered and concentrated in vacuo to afford the crude product as an oil. Purification by Isco chromatography afforded tert-butyl 4-(6-fluoroquinolin-4- yl)piperazine-1-carboxylate as a solid (719.3 mg; 77% yield). MS(ES): m\/z = 332 [M+H]. tp. = 0.70 mm (Method A). ?H NMR (400MHz, DMSO-d6) oe 8.70 (d, J=4.9 Hz,1H), 8.04 (dd, J=9.2, 5.6 Hz, 1H), 7.76 – 7.58 (m, 2H), 7.07 (d, J=5.0 Hz, 1H), 3.71 – 3.54 (m, 4H), 3.14 – 3.01 (m, 4H), 1.44 (s, 9H).<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Chloro-6-fluoroquinoline, and friends who are interested can also refer to it.<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Chloro-6-fluoroquinoline, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[441,427],"tags":[126],"class_list":["post-2125","post","type-post","status-publish","format-standard","hentry","category-391-77-5","category-quinolines-derivatives","tag-m-w100-200"],"yoast_head":"\nNew downstream synthetic route of 391-77-5<\/title>\n<meta name=\"description\" content=\"Related Products of 391-77-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 391-77-5 name is 4-Chloro-6-fluoroquinoline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=2125\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New downstream synthetic route of 391-77-5\" \/>\n<meta property=\"og:description\" content=\"Related Products of 391-77-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 391-77-5 name is 4-Chloro-6-fluoroquinoline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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The downstream synthesis method of this compound is introduced below.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/www.pyrazoles-derivatives.com\/?p=2125","og_locale":"en_US","og_type":"article","og_title":"New downstream synthetic route of 391-77-5","og_description":"Related Products of 391-77-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 391-77-5 name is 4-Chloro-6-fluoroquinoline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.","og_url":"http:\/\/www.pyrazoles-derivatives.com\/?p=2125","og_site_name":"pyrazoles-derivatives","article_published_time":"2021-03-09T18:49:46+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"http:\/\/www.pyrazoles-derivatives.com\/?p=2125","url":"http:\/\/www.pyrazoles-derivatives.com\/?p=2125","name":"New downstream synthetic route of 391-77-5","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2021-03-09T18:49:46+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Related Products of 391-77-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 391-77-5 name is 4-Chloro-6-fluoroquinoline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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