{"id":2119,"date":"2021-03-10T02:49:46","date_gmt":"2021-03-09T18:49:46","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2119"},"modified":"2021-03-10T02:49:46","modified_gmt":"2021-03-09T18:49:46","slug":"extracurricular-laboratory-synthetic-route-of-13669-51-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2119","title":{"rendered":"Extracurricular laboratory: Synthetic route of 13669-51-7"},"content":{"rendered":"

Reference of 13669-51-7<\/a>, These common heterocyclic compound, 13669-51-7, name is Quinolin-3-ylmethanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

3-(Chloromethyl)quinoline hydrochloride MDE 32004 To a solution of quinolin-3-ylmethanol MDE 32002 (0.26 g, 1.63 mmol) in dry CH2Cl2 (10 mL) at 0 C. under N2 in a 25 mL round-bottomed flask equipped with a magnetic stirrer was added dropwise SOCl2 (2.4 mL, 33.1 mmol) and the mixture was stirred for 1 h at RT. The volatiles were then removed at 40 C. under vacuum and the residue was taken up in CH2Cl2 (20 mL) before concentration back to dryness at 40 C. under vacuum (done 3 times) to give 3-(chloromethyl)quinoline hydrochloride MDE 32004 as an off-white solid (301 mg, 85% yield). MW: 214.09; Yield: 85%; Off-white solid; Mp ( C.): 192.1 1H-NMR (CD3OD, delta): 5.10 (s, 2H, CH2), 8.01-8.06 (m, 1H, ArH), 8.24-8.26 (m, 1H, ArH), 8.31 (d, 1H, J=8.4 Hz, ArH), 8.39 (d, 1H, J=8.4 Hz, ArH), 9.32 (s, 1H, ArH), 9.41-9.42 (m, 1H, ArH). 13C-NMR (CD3OD, delta): 42.3, 121.5, 130.3, 130.7, 131.9, 134.5, 136.8, 138.6, 146.5, 147.8. MS-ESI m\/z (% rel. Int.): 178 ([MH]+, 35Cl, 100), 180 ([MH]+, 37Cl, 32).<\/p>\n

The synthetic route of 13669-51-7 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 13669-51-7 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[435,427],"tags":[126],"class_list":["post-2119","post","type-post","status-publish","format-standard","hentry","category-13669-51-7","category-quinolines-derivatives","tag-m-w100-200"],"yoast_head":"\nExtracurricular laboratory: Synthetic route of 13669-51-7<\/title>\n<meta name=\"description\" content=\"Reference of 13669-51-7, These common heterocyclic compound, 13669-51-7, name is Quinolin-3-ylmethanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2119\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Extracurricular laboratory: Synthetic route of 13669-51-7\" \/>\n<meta property=\"og:description\" content=\"Reference of 13669-51-7, These common heterocyclic compound, 13669-51-7, name is Quinolin-3-ylmethanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2119\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-09T18:49:46+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2119\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2119\",\"name\":\"Extracurricular laboratory: Synthetic route of 13669-51-7\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-03-09T18:49:46+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Reference of 13669-51-7, These common heterocyclic compound, 13669-51-7, name is Quinolin-3-ylmethanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2119#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=2119\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2119#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Extracurricular laboratory: Synthetic route of 13669-51-7\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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